Patients with moderate-to-severe acne were assigned equally (50 patients each) to one of the two treatment regimens using block randomization technique, Group A was given lowdose continuous regimen - 20 mg of oral isotretinoin once daily for 4 months and Group B was given low-dose intermittent regimen
- 20 mg of oral isotretinoin once daily for 1 week out of every 4 weeks.
Relapse-free survival was significantly inferior with the intermittent regimen
Also, the results cannot be extrapolated to those who have less-frequent sexual intercourse, who would thus be taking TDF-FTC on a more intermittent regimen
than was seen in this trial, they said.
It was found that few students had misconcepts on intermittent regimen
of DOTS, chemoprophylaxis.
It is also plausible that the continuous nature of the infusion promoted sequestration and excretion mechanisms in these patients resulting in more efficient autoregulation versus the sporadic nature of potassium infusions in the intermittent regimen
As of today if you look at the National TB Control Program, I think the failure rate in PLHIVs is comparable to HIV negative patients, if we follow the thrice a week intermittent regimen
. But the only problem is of relapse.
As placebo patients from the halted study cross over to vismodegib, they are being dosed on an intermittent regimen
consisting of repeated cycles of 3 months on daily therapy, then 2 months off, with the aim of minimizing side effects.
"This is the first real demonstration of the efficacy of an intermittent regimen
with a bisphosphonate," commented Dr.
Continuous dosing may also be helpful if the intermittent regimen
is not working.
An intermittent high-dose budesonide regimen and a daily low-dose regimen resulted in similar reductions in asthma exacerbations in preschool children with recurrent wheezing, but the intermittent regimen
was associated with significantly less drug exposure.
Continuous dosing may help if the intermittent regimen
is not working.