In mitochondria-rich cells, cytoplasm degradation was observed, with disappearance or disorganization of endoplasmic reticulum network and mitochondrial degradation evidenced by mitochondrial crest degeneration and dilation of intermembrane space
The mitochondrion (plural mitochondria) is a double membrane-bound organism that consists of the outer mitochondrial membrane (OMM), intermembrane space
, inner mitochondrial membrane, and matrix space, which is prevalent in all mammalian eukaryotic cells other than mature erythrocytes.
Hyperpolarized mitochondria have an elevated transmembrane potential because of the excess of H+ ions in the intermembrane space
in comparison with the matrix.
The proton gradient is used to fuel pyruvate uptake from the cytosol into the matrix via pyruvate transporter, pumping of sodium, potassium from the matrix into the intermembrane space
/cytosol, phosphate transport from the cytosol into the matrix space, and ATP generation by the F0F1-ATPase.
Practically, a mitochondrion is a balloon inside the balloon where inner and outer membranes create two separate internal compartments: intermembrane space
and matrix space .
Microglia are small cells with electron-dense nucleus and cytoplasm in which cisternae of endoplasmic reticulum have a lighter intermembrane space
. (G) Mesaxon myelination on the axial cylinder.
Central to the organelle are also the aqueous compartments, the mitochondrial matrix, and the intermembrane space
. Tight regulation of ion flow between these distinct pockets is essential for the ETC's core functions.
RAB5B is a member of the RAS oncogene family and SUOX, sulfite oxidase, is a homodimeric protein enzyme localized to the intermembrane space
of mitochondria, which catalyzes oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine.
If PpPBP functions in the final step of peptidoglycan synthesis in moss plastids, similar to that in bacteria, PpPBP must localize to the intermembrane space
of the plastid envelope.
The mitochondrial pathway is initiated by the release of apoptotic factors such as cytochrome c, apoptosis inducing factor (AIF) and endonuclease G from the mitochondrial intermembrane space
by mitochondrial outer membrane permeabilization (MOMP), which is a complex process that involves numerous molecular players including Bcl-2 family (Brenner and Grimm, 2006; Kuwana and Newmeyer, 2003).
It is present in all human cells in various locations, including the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane space
. (50) Its primary function is to act as an antioxidant enzyme, lowering the steady-state concentration of superoxide.