intermediate syndrome

intermediate syndrome

Toxicology A condition caused by organophosphorus insecticides, characterized by chronic distal motor polyneuropathy, possibly due to a neuromuscular junction defect Clinical 5% to 10% of those exposed develop paralysis of cranial motor nerves, proximal limb, cervical flexor and respiratory muscles; onset, 1-4 days after a cholinergic phase

Patient discussion about intermediate syndrome

Q. What is the difference between Asperger's Syndrome and Autism? My 3 year old nephew has been diagnosed with Asperger's Syndrome. Is this the same as Autism?

A. Here is a video which explains about Asperger's Syndrome, which might help you understand the difference between that and autism:
http://www.5min.com/Video/What-is-Asperger-Syndrome-6213

Q. what is the difference between two. which is mild one( aspergers syndrome and autism)

A. Asperger disorder is indeed the milder disorder on the autistic spectrum of disorders. It is a condition in which the child is markedly impaired in social relatedness and shows repetitive and stereotyped patterns of behavior without a delay in language development or mental retardation. In contrast, autism is characterized by problems with language and social skills, repetitive behavior, as well as mental retardation in many cases.

You may read more here:
www.nlm.nih.gov/medlineplus/autism.html

More discussions about intermediate syndrome
References in periodicals archive ?
3 Fatalities are related to cholinergic syndrome in acute phases and intermediate syndrome (IS) in late-onset cases.
Organophosphates (OP) may cause toxic effects that are classified in three stages; cholinergic syndrome, intermediate syndrome and organophosphate induced delayed neuropathy (OPIDN).
Intermediate syndrome in which cranial nerve palsies, proximal muscle weakness and respiratory muscle weakness are common and patients often require respiratory support and organophosphate induced delayed polyneuropathy [OPDN].
29 The intermediate syndrome is a clinical condition characterised by a paralysis in the respiratory muscles, weakness in the proximal limb muscles, and motor cranial nerve involvement in OP poisoning and it leads to a poor clinical outcome.
Organophosphorus poisoning could manifest in three phases (acute cholinergic effects, intermediate syndrome and organophosphate-induced delayed neuropathy).
Intermediate syndrome was defined as proximal muscle weakness and/or respiratory distress occurring 24 to 96 hours after OP ingestion with or without the need for mechanical ventilation (9).
Another 3 patients developed intermediate syndrome on day 3 had initial creatine kinase level 1138 IU/L and concluded serum creatine kinase can be an efficient biomarker in case of acute organophosphorus poisoning.
7,8,9) Intermediate syndrome and organophosphorus induced delayed neuropathy (COPIND).
These irreversible inhibitors of cholinesterase produce three wells-recognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilatory care is necessary; and delayed polyneuropathy.
The Study includes age and sex profile, type of organophosphorous compound consumed, incidence of intermediate Syndrome in organophosphorous poisoning, the circumstances leading to Poisoning.
Of these, 682 patients had the history of ingestion of organo-phosphorus poisoning and among total cases, 64 patients went into intermediate syndrome during the course of treatment.

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