intermediate syndrome

intermediate syndrome

Toxicology A condition caused by organophosphorus insecticides, characterized by chronic distal motor polyneuropathy, possibly due to a neuromuscular junction defect Clinical 5% to 10% of those exposed develop paralysis of cranial motor nerves, proximal limb, cervical flexor and respiratory muscles; onset, 1-4 days after a cholinergic phase
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Patient discussion about intermediate syndrome

Q. What is the difference between Asperger's Syndrome and Autism? My 3 year old nephew has been diagnosed with Asperger's Syndrome. Is this the same as Autism?

A. Here is a video which explains about Asperger's Syndrome, which might help you understand the difference between that and autism:
http://www.5min.com/Video/What-is-Asperger-Syndrome-6213

Q. what is the difference between two. which is mild one( aspergers syndrome and autism)

A. Asperger disorder is indeed the milder disorder on the autistic spectrum of disorders. It is a condition in which the child is markedly impaired in social relatedness and shows repetitive and stereotyped patterns of behavior without a delay in language development or mental retardation. In contrast, autism is characterized by problems with language and social skills, repetitive behavior, as well as mental retardation in many cases.

You may read more here:
www.nlm.nih.gov/medlineplus/autism.html

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References in periodicals archive ?
Fasciculation cramp syndrome preceding anterior horn cell disease:an intermediate syndrome? J Neurol Neurosurg Psychiatry 2011; 82(4): 459-69.
* The majority of maternal deaths occurred during the acute cholinergic crisis and intermediate syndrome phases of organophosphate poisoning.
Acute cholinergic crisis and respiratory failure, such as Intermediate Syndrome are frequently related to death.7 Mortality rates are reported to be as high as 10-20% in the literature.1,6-9
Organophosphates (OP) may cause toxic effects that are classified in three stages; cholinergic syndrome, intermediate syndrome and organophosphate induced delayed neuropathy (OPIDN).
Intermediate syndrome in which cranial nerve palsies, proximal muscle weakness and respiratory muscle weakness are common and patients often require respiratory support and organophosphate induced delayed polyneuropathy [OPDN].
Serum glucose levels in patients with OP poisoning have been investigated in various studies.29,37,38 In one such study, the mean glucose level was 144 mg/dl and it was determined to be an independent factor in the development of the intermediate syndrome.29 The intermediate syndrome is a clinical condition characterised by a paralysis in the respiratory muscles, weakness in the proximal limb muscles, and motor cranial nerve involvement in OP poisoning and it leads to a poor clinical outcome.39,40 Another study pointed out a mean glucose level of 145mg/dl and 67.7% patients had hyperglycaemia.
Organophosphorus poisoning could manifest in three phases (acute cholinergic effects, intermediate syndrome and organophosphate-induced delayed neuropathy).
Outcomes evaluated included mortality, need for mechanical ventilation and incidence of intermediate syndrome. Intermediate syndrome was defined as proximal muscle weakness and/or respiratory distress occurring 24 to 96 hours after OP ingestion with or without the need for mechanical ventilation (9).
[6,7] Any ongoing respiratory difficulty and neurological weakness may be due to delayed neurotoxic effects, such as intermediate syndrome, [6,8] or complications secondary to the acute crisis, e.g.
Another 3 patients developed intermediate syndrome on day 3 had initial creatine kinase level 1138 IU/L and concluded serum creatine kinase can be an efficient biomarker in case of acute organophosphorus poisoning.
(7,8,9) Intermediate syndrome and organophosphorus induced delayed neuropathy (COPIND).
Intermediate Syndrome: weakness of the upper extremities and neck muscles, cranial nerve palsies and secondary respiratory arrest.

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