intermediate lymphocytic lymphoma
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Related to intermediate lymphocytic lymphoma: chronic lymphocytic lymphoma
mantle cell lymphomaAn uncommon low-to-intermediate-grade non-Hodgkin lymphoma (NHL), which is a malignancy of naive B cells. It comprises ± 6% of NHL cases in the US, slightly higher in Europe. It is hard to treat and harder to cure. It is more common in men ≥ age 55.
Massive splenomegaly, generalised lymphadenopathy, 1/3 present with “B” symptoms—i.e., fever, weight loss, night sweats.
Nodes, spleen, bone marrow, Waldeyer's ring, GI (lymphomatous polyposis), gallbladder.
• Small lymphocytic lymphoma/CLL
• MALT lymphoma
• Follicular lymphoma
Prognosis MCLs are often aggressive and involve the spleen, liver, bone marrow; they are regarded as incurable. Median 2- to 5-year survival. Cases with mutations in the immunoglobulin gene have better prognosis—40% achieve complete remission with chemotherapy.