intermediate filament


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intermediate filament

n.
Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.

intermediate filament

Abbreviation: IF
Slender proteins found in all eukaryotic cells, measuring about 8 to 12 nm in diameter. Intermediate filaments are composed of proteins including desmin, keratins, lamins, and vimentin and together with microtubules and microfilaments form the cytoskeleton. Some malignant cells can be identified by the specific proteins in their intermediate filaments.
See also: filament
References in periodicals archive ?
Characterization of a hair (wool) keratin intermediate filament gene domain.
The Z-lines are the anchoring site of [alpha]-actinin, titin and several intermediate filaments, including desmin and vimentin.
In mitotically active cells, nestin plays an important role, regulated by phosphorylation, in the assembly and disassembly of intermediate filaments, which contributes to remodeling the cytoskeleton of the cells.
Neuronal intermediate filaments and ALS: a new look at an old question.
Figure 14: infectious muscle 24 hours after injection, Desmin intermediate filament (arrowhead) within the Myocytes that surrounding by inflammatory cells (arrow) is seen.
Liao, "'Heads and tails'of intermediate filament phosphorylation: multiple sites and functional insights," Trends in Biochemical Sciences, vol.
(26) KFAP's also known as intermediate filament associated proteins are composed of filaggrin, tricohyalin, desmosomal proteins and proteins of cornified cell envelope (loricrin, involucrin and small proline rich proteins).
Intermediate filaments (IFs) participate in key mechanical functions and play a role in preventing excess large cell stretch.
It consists mainly of intermediate filaments called lamins and microfilaments cal led act ins and DNA topoisomeraseII (Fig.1).
In peritoneal cells, bundles of intermediate filaments appear to be broken into short fragments (Fig.
Arrow indicates process of fibrous astrocyte contained bundles of parallel extending intermediate filament. (F) Astrocyte with cytoplasm rich in next organelles: Golgi complex, mitochondria, multivesicular bodies, and greatly enhanced, almost circular, cisterns of rough endoplasmic reticulum.

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