interleukin-6


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in·ter·leu·kin-6

(in'tĕr-lū'kin),
A cytokine derived from macrophages and endothelial cells that increases synthesis and secretion of immunoglobulins by B lymphocytes; also induces acute-phase proteins. In hepatocytes, it induces acute-phase reactants.
Synonym(s): B-cell stimulatory factor 2, interferon-β2

interleukin-6 (IL-6)

a cytokine derived from fibroblasts, macrophages, and tumor cells. It is an antiviral protein that is also used in the treatment of some types of cancer. Also called beta2-interferon.

IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.

in·ter·leu·kin-6

(in'tĕr-lū'kin)
A cytokine derived from fibroblasts, macrophages, and tumor cells that increases synthesis and secretion of immunoglobulins by B lymphocytes.
Synonym(s): B-cell stimulatory factor 2.

interleukin-6

A CYTOKINE produced by HELPER T CELLS, MACROPHAGES, fibroblasts and MAST CELLS that promotes the growth and differentiation of B cells, T cells and blood stem cells and the induction of ACUTE PHASE PROTEINS.
References in periodicals archive ?
Biochemical Assessment: Enzyme linked Immunoassay technique was used for biochemical assessment of Interleukin-6 on ELISA kits.
The extra angiotensin did not much affect the retinal vessels of mice lacking interleukin-6 but vessels in the normal mouse retina mimicked the inflammatory reaction found in diabetic retinopathy.
In both groups, interleukin-6 was significantly higher at 8 hours and following delivery, compared with the baseline measurement, but no significant differences were found between the two groups in interleukin-6 levels at any of the measurement intervals.
In addition, smoke-exposed mice fed antioxidant supplements showed significantly lower production of interleukin-6 compared to smoke-exposed mice on a control diet.
In vivo vitamin E administration attenuates interleukin-6 and interleukin-1beta responses to an acute inflammatory insult in mouse skeletal and cardiac muscle.
When white blood cells encounter lipid A, they make a cascade of proteins -- such as tumor necrosis factor (TNF), interleukin-1, interleukin-6, and interleukin-8 - that stimulate the immune system.
Adherence to the Mediterranean diet was associated with reduced levels of interleukin-6 (P<0.
This might involve prompting cells to make such cytokines as interleukin-2 or interleukin-6 -- immune system stimulators known to activate HIV.