interleukin-6


Also found in: Dictionary, Thesaurus, Encyclopedia.

in·ter·leu·kin-6

(in'tĕr-lū'kin),
A cytokine derived from macrophages and endothelial cells that increases synthesis and secretion of immunoglobulins by B lymphocytes; also induces acute-phase proteins. In hepatocytes, it induces acute-phase reactants.
Synonym(s): B-cell stimulatory factor 2, interferon-β2

IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.

in·ter·leu·kin-6

(in'tĕr-lū'kin)
A cytokine derived from fibroblasts, macrophages, and tumor cells that increases synthesis and secretion of immunoglobulins by B lymphocytes.
Synonym(s): B-cell stimulatory factor 2.

interleukin-6

A CYTOKINE produced by HELPER T CELLS, MACROPHAGES, fibroblasts and MAST CELLS that promotes the growth and differentiation of B cells, T cells and blood stem cells and the induction of ACUTE PHASE PROTEINS.
References in periodicals archive ?
But Wedell-Neergaard and co-senior study author Helga Ellingsgaard of the University of Copenhagen suspected that interleukin-6 could also play an important role because it regulates energy metabolism, stimulates the breakdown of fats in healthy people, and is released from skeletal muscle during exercise.
Keywords: Endometrial thickness, Tumour necrosis factor alpha, Interleukin-6, Infertility, Intracytoplasmic sperm injection.
Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice.
Interleukin-6 and Interleukin-17 gene polymorphisms and celiac disease susceptibility.
Hirai, "A case of POEMS syndrome with high concentrations of interleukin-6 in pericardial fluid," Journal of Internal Medicine, vol.
The association between the patient categories (i.e., ART naive versus ART experienced) and serum interleukin-6 levels was not affected after adjustment for the gender of the participants, with the regression coefficient for patient category reducing by 0.13% (b = 15.76 versus b= 15.74).
Chronic periodontitis enhances the risk of coronary heart disease by elevating the serum concentration of CRP (C-reactive protein)18 and IL-6 (Interleukin-6), which decrease in concentration after treatment.
Supplementation with Cistanche has been shown to increase naive T cells and natural killer (NK) cells while decreasing memory T cells and pro-inflammatory interleukin-6. (43) One of the characteristics of people who live over 100 years is low levels of interleukin-6.
Interleukin-6 (IL-6) is confirmed proinflammatory cytokine which plays central role in the inflammatory response following cerebral hypoxia ischemia (Loddick et al.
KEY WORDS: Autoimmune rheumatic disease Detection Diagnosis and treatment Soluble interleukin-6 receptor.
[1] entitled "can tumor necrosis factor-[alpha] and interleukin-6 be used as prognostic markers of infection following ureteroscopic lithotripsy?" in which they report preoperative and postoperative serum interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) levels in patients with urolithiasis.