interleukin-4


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in·ter·leu·kin-4

(in'tĕr-lū'kin),
A cytokine derived from T4 lymphocytes that causes differentiation of B lymphocytes. Promotes Ig class switch and production of IgE. It stimulates DNA biosynthesis.

interleukin-4 (IL-4)

an immune-response protein that is a growth factor for activated B cells, resting T cells, and mast cells. Also called B cell stimulating factor-1.

IL4

A gene on chromosome 5q31.1 that encodes interleukin-4, a pleiotropic cytokine produced by activated T cells, which participates in several B-cell activation processes. IL-4 is a ligand for IL4 receptor (as is IL13), and it induces the expression of class II MHC molecules on resting B-cells. It activates several B-cell and other cell processes; is a co-stimulator of DNA-synthesis; enhances secretion and cell surface expression of IgE and IgG1; and regulates expression of the low-affinity Fc receptor for IgE (CD23) on lymphocytes and monocytes.

in·ter·leu·kin-4

(in'tĕr-lū'kin)
A cytokine derived from T4 lymphocytes that causes differentiation of B lymphocytes.
Synonym(s): B-cell differentiating factor.

interleukin-4

A CYTOKINE produced by HELPER T CELLS, MAST CELLS and bone marrow that has a wide range of actions. It promotes the proliferation of B cells, T cells, MAST CELLS and blood forming cells; it induces the formation of MAJOR HISTOCOMPATIBILITY COMPLEXES on B cells; and it is believed to promote class switching in B cells from one class of antibodies to another.
References in periodicals archive ?
Previous studies in people have shown that interleukin-4 causes few side effects.
Over the next year, we also expect to initiate clinical trials of a Vascular Endothelial Growth Factor (VEGF) Trap to block angiogenesis and vascular permeability in settings of cancer and other conditions and a dual Trap for both interleukin-4 and interleukin-13 for asthma/allergies.
Regeneron's current preclinical development programs include several cytokine antagonists (including an interleukin-1 trap for rheumatoid arthritis, and interleukin-4 and interleukin-4/13 traps for asthma and allergic disorders), an antagonist for vascular endothelial growth factor (VEGF) for cancer, and second generation AXOKINE(R) ciliary neurotrophic factor for obesity.