interleukin-4


Also found in: Dictionary, Thesaurus, Encyclopedia.

in·ter·leu·kin-4

(in'tĕr-lū'kin),
A cytokine derived from T4 lymphocytes that causes differentiation of B lymphocytes. Promotes Ig class switch and production of IgE. It stimulates DNA biosynthesis.

IL4

A gene on chromosome 5q31.1 that encodes interleukin-4, a pleiotropic cytokine produced by activated T cells, which participates in several B-cell activation processes. IL-4 is a ligand for IL4 receptor (as is IL13), and it induces the expression of class II MHC molecules on resting B-cells. It activates several B-cell and other cell processes; is a co-stimulator of DNA-synthesis; enhances secretion and cell surface expression of IgE and IgG1; and regulates expression of the low-affinity Fc receptor for IgE (CD23) on lymphocytes and monocytes.

in·ter·leu·kin-4

(in'tĕr-lū'kin)
A cytokine derived from T4 lymphocytes that causes differentiation of B lymphocytes.
Synonym(s): B-cell differentiating factor.

interleukin-4

A CYTOKINE produced by HELPER T CELLS, MAST CELLS and bone marrow that has a wide range of actions. It promotes the proliferation of B cells, T cells, MAST CELLS and blood forming cells; it induces the formation of MAJOR HISTOCOMPATIBILITY COMPLEXES on B cells; and it is believed to promote class switching in B cells from one class of antibodies to another.
References in periodicals archive ?
Tekcan et al., "Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis," Gene, vol.
Rowley, "Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q)," Blood, vol.
Hodgkin lymphoma therapy with interleukin-4 receptor-directed cytotoxin in an infiltrating animal model.
Interleukin-4 (IL-4), a 20-kDa polypeptide secreted by T cells and mast cells, has pleiotropic effects on hematopoietic cells (Paul 1991).
Whether a shortage of interleukin-4 and interleukin-10 sabotages nerve terminals in people is unclear, she says, since the authors of the new study didn't measure all cytokines that might have an effect.
The researchers instructed 22 patients with moderate-to-severe psoriasis to inject themselves with interleukin-4 three times a day for 6 weeks.
In allergic individuals, interleukin-4 (IL-4) is increased in the serum and bronchoalveolar lavage fluid.
The treatment also boosted concentrations of the anti-inflammatory protein interleukin-4. Moreover, compared with the other mice, the animals given the VIP treatment had lower concentrations of self-attacking antibodies in their blood and less of an enzyme produced by macrophages that breaks down cartilage.
Dupixent is a human monoclonal antibody specifically designed to inhibit signalling of interleukin-4 (IL-4) and interleukin-13 (IL-13).
Researchers studying the function of an immune-system messenger called interleukin-4 (IL-4) have inadvertently created a strain of mice that develops osteoporosis.
It is a targeted form of immunotherapy designed to purge tumor cells and adjacent immunosuppressive cells in the tumor microenvironment that over-express the interleukin-4 receptor, which is common in a majority of patients with rGB.
However, that chain makes cells listen also to the messages carried by interleukin-4 (IL-4) and interleukin-7 (IL-7), says Warren J.