IL28B

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IL28B

A gene on chromosome 19q13.13 that encodes interleukin-28B, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28B is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
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Single nucleotide polymorphism (SNP) of interleukin-28B (IL28B) host genotype (rs8099917) [11] was also evaluated after obtaining written informed consent for genome analysis from each patient.
Age, sex, time of previous entecavir therapy, HBe Ag positivity, HBV genotype, HBs Ag level, and interleukin-28B polymorphism were not significant.
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.
Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes.
Meta-analysis: Implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C.
Rs12979860 and rs8099917 single nucleotide polymorphisms of interleukin-28B gene: Simultaneous genotyping in Caucasian patients infected with hepatitis C virus.
Variations in the interleukin-28B gene, which encodes an immune system signaling protein, might account for some of the differences in protection among people getting the flu shot.
But it would need to be borne out in tests in animals and people to establish that revving up antibody production by undercutting interleukin-28B is a net gain--and doesn't diminish some other form of immune protection, he says.
KEY WORDS: Hepatitis C virus Interleukin-28B Single nucleotide polymorphism.
Cheng et al., "Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C," Hepatology, vol.
Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients.