interleukin-18


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Related to interleukin-18: Il-18

in·ter·leu·kin-18

(in'tĕr-lū'kin),
A cytokine produced by macrophages; a potent inducer of interferon-γ by T cells and NK cells.

IL18

A gene on chromosome 11q22.2-q22.3 that encodes IL-18, a proinflammatory cytokine that increases natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

in·ter·leu·kin-18

(in'tĕr-lū'kin)
A cytokine made by macrophages; a potent inducer of interferon-γ by T cells and natural killer cells.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.
See also: interleukin

interleukin-18

,

IL-18

A cytokine produced by macrophages that stimulates the production of gamma interferon (IFN?) and other chemical mediators that enhance cell-mediated immune responses. Interleukin-18 is similar in structure to IL-1.
References in periodicals archive ?
Interleukin-18 as a diagnostic marker and indicator of disease severity in adult-onset Still's disease.
Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer.
Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers.
Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002.
Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.
The Company's patent-pending gene, apoptosis eucaryotic initiation Factor 5A ("Factor 5A"), has been correlated in ischemic heart tissue to two cytokines, interleukin-1 beta and interleukin-18 ("IL-1" and "IL-18").
The Phase 2 study, which is expected to begin before the end of the year, will be designed to confirm the potential impact of NP001 on two inflammation biomarkers: interleukin-18 (IL-18) and the presence of lipopolysaccharide (LPS) in the blood.
Interleukin-18 plasma levels are increased in patients with sepsis compared to severely injured patients.
Most patients in the study who responded to NP001, such as having their progression halted, had an elevated biomarker of inflammation, interleukin-18 (IL-18), and were positive for lipopolysaccharide (LPS) in blood plasma at baseline, both of which are believed to play a role in the progression of ALS.