interleukin-18


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Related to interleukin-18: Il-18

in·ter·leu·kin-18

(in'tĕr-lū'kin),
A cytokine produced by macrophages; a potent inducer of interferon-γ by T cells and NK cells.

IL18

A gene on chromosome 11q22.2-q22.3 that encodes IL-18, a proinflammatory cytokine that increases natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

in·ter·leu·kin-18

(in'tĕr-lū'kin)
A cytokine made by macrophages; a potent inducer of interferon-γ by T cells and natural killer cells.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.
See also: interleukin

interleukin-18

,

IL-18

A cytokine produced by macrophages that stimulates the production of gamma interferon (IFN?) and other chemical mediators that enhance cell-mediated immune responses. Interleukin-18 is similar in structure to IL-1.
References in periodicals archive ?
Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies.
Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions.
A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3 -kinase-dependent signal transduction.
Altered expression of interleukin-18 in the ectopic and eutopic endometrium of women with endometriosis.
Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers.
Abbott scientists reported in the November 2007 issue of Nature Biotechnology, a scientific journal, that they created antibodies that latched onto Interleukin-12 and Interleukin-18, two components of the immune system.
3]-exposed rats have shown that macrophages release tumor necrosis factor-[alpha] and interleukin-18, leading, through a series of steps, to NO production and ultimately tissue injury.
The underlying pathophysiology of PRES complicated with autoimmune diseases are as follows: theories including dysfunction of autoregulatory cerebral perfusion mechanisms and endothelia, inflammasome activation of interleukin-18 and neutrophil extracellular trap formation and the presence of autoantibodies (N-methyl-D-aspartate receptor and anti-aquaporin 4) were studied.