Gurney, "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
," The Journal of Biological Chemistry, vol.
Relapse Laboratory tests Yes (n = 45) No (n = 72) Cytokines at diagnosis IL-4 (pg/mL) 21.1 [+ or -] 5.8 19.9 [+ or -] 6.1 IL-17 (pg/mL) 10.9 [+ or -] 3.7 10.1 [+ or -] 3.2 IFN-[gamma] (pg/mL) 130.4 [+ or -] 65.4 124.5 [+ or -] 55.8 Cytokines at cessation IL-4 (pg/mL) 15.1 [+ or -] 5.9 12.8 [+ or -] 4.7 IL-17 (pg/mL) 8.9 [+ or -] 3.1 7.1 [+ or -] 2.7 IFN-[gamma] (pg/mL) 122.4 [+ or -] 54.9 118.9 [+ or -] 51.7 Laboratory tests p value Cytokines at diagnosis IL-4 (pg/mL) 0.29 IL-17 (pg/mL) 0.22 IFN-[gamma] (pg/mL) 0.60 Cytokines at cessation IL-4 (pg/mL) 0.022 * IL-17 (pg/mL) 0.001 * IFN-[gamma] (pg/mL) 0.73 GD: Graves' disease; IL-4: interleukin-4; IL-17: interleukin-17
; IFN-[gamma]: interferon-[gamma].
Flavell, "Interleukin-22 but not interleukin-17
provides protection to hepatocytes during acute liver inflammation," Immunity, vol.
A, Concentrations of 25-hydroxyvitamin D (25(OH) D), transforming growth factor [beta] (TGF-[beta]), and B, interleukin-17
(IL-17) and interleukin-23 (IL-23) in decidual tissues by enzyme-linked immunosorbent assay, in the recurrent spontaneous abortion (RSA) group compared with the control group.
stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2dependent NF-kappaB and C/EBPbeta activation.
Choi et al., "Investigating the relationship between serum interleukin-17
levels and systemic immune-mediated disease in patients with dry eye syndrome," Korean Journal of Ophthalmology, vol.
Role of interleukin-17
and the neutrophil in asthma.
Expression of interleukin-17
associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection.
Th17 cells are characterized by the production of interleukin-17
. Th17 cell development depend upon the presence of interleukin-23 (a monocyte product) and also IL6 and TGF-b.
He et al., "Interleukin-17
mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis," Multiple Sclerosis, vol.
(9) A number of experiments targeting interleukin-17
(IL-17) and T helper 17 (TH17) in mouse models have led to the discovery of the role played by such molecules in tissue inflammation, autoimmunity, and host defense mechanisms (Miossec & Kolls, 2012).
Regulatory effects of interferon-b on osteopontin and interleukin-17
expression in multiple sclerosis.