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Related to interleukin-15: Interleukin 13, Interleukin 16, Interleukin 17


A cytokine derived from T cells that stimulates T cell proliferation and NK cell activation.

interleukin-15 (IL-15)

a growth factor that enhances peripheral blood T cell production.


A gene on chromosome 4q31 that encodes interleukin-15, a cytokine which regulates T and natural killer cell activation and proliferation. IL15 shares many biological activities with IL-2: they both bind common haematopoietin receptor subunits and may compete for the same receptor, thus having a ying-yang relationship with each other. IL15 activates JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5 and STAT6.


A cytokine derived from T cells that stimulates T-cell proliferation and natural killer cell activation.
References in periodicals archive ?
Interleukin-15 increases myosin accretion in human skeletal myogenic cultures.
Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats.
Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.
Interleukin-15 and its role in chronic inflammatory disease.
Regula-tion of lymphoid homeostasis by interleukin-15.
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular patho-gens.
Altor is a venture-backed, privately held biotechnology company developing targeted immunotherapies for treating cancer, viral infections, and inflammatory diseases based on its proprietary STAR(TM), tissue factor antagonist and interleukin-15 platform technologies.
Interleukin-15 has also been shown to play an important role in the induction of the allergic process.
Interleukin-15 modulates both T and NK cell-mediated inflammatory responses, probably by sharing many functional activities of IL-2, whose production and secretion is induced by several proinflammatory cytokines such as IL-l [beta], TNF-[alpha] and IFN-[gamma].