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Related to interleukin-15: Interleukin 13, Interleukin 16, Interleukin 17


A cytokine derived from T cells that stimulates T cell proliferation and NK cell activation.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 4q31 that encodes interleukin-15, a cytokine which regulates T and natural killer cell activation and proliferation. IL15 shares many biological activities with IL-2: they both bind common haematopoietin receptor subunits and may compete for the same receptor, thus having a ying-yang relationship with each other. IL15 activates JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5 and STAT6.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A cytokine derived from T cells that stimulates T-cell proliferation and natural killer cell activation.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Kastin et al., "Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Ra receptor," Psychoneuroendocrinology, vol.
MacKenzie et al., "Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes," Obesity, vol.
Tian, "Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL," Cytotherapy, vol.
Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.
The largest group of upregulated genes included immunomodulatory gene regulators, cytokines, such as interleukin-15 (IL-15), chemokine (C-X-C motif) ligand 10 (CXCL-10), and vascular endothelial growth factor C (VEGF-C), and cytokine receptors, such as interleukin-15 receptor alpha (IL-15RA).
These signals may be critical for several aspects of NK cell biology including development, peripheral homeostasis, and /or activa-tion.10 IL-15 inhibits apoptosis of lymphocytes and hepatocytes induced by cytokine deprivation, anti-Fas, anti-CD3, dexamethasone, or anti-IgM.2 There is in-creasing evidence that IL-15 may play an important role in protective immune response, allograft rejection and pathogenesis of autoimmune diseases, where mono-nuclear cells infiltration is a hallmark feature.13 Interleukin-15 (IL-15) has pivotal roles in the control of the life and death of lymphocytes.
Are interleukin-2 and interleukin-15 tumor promoting factors for human non-hematopoietic cells?
The synthetic creation is dubbed GIFT-15, short for its two components, interleukin-15 and a compound called GMCSF.
The 2006 edition discusses the risks and benefits of COX-2 inhibitors, the genetics of rheumatoid arthritis, therapeutic tissue engineering, Interleukin-15, primary Sjogren's syndrome, and the ultrasound diagnosis of vasculitis.
The patent covers a bispecific antibody, where one binding arm of the antibody is to the tumor and the other is to a region of a cytokine called interleukin-15 (alpha).
Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15.