interleukin-13


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in·ter·leu·kin-13

(in'tĕr-lū'kin),
A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation; its activity overlaps that of IL-4.

IL13

A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.

Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.

in·ter·leu·kin-13

(in'tĕr-lū'kin)
A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation.

interleukin-13

A CYTOKINE produced by T LYMPHOCYTES that inhibits mononuclear cell inflammation.
References in periodicals archive ?
Node, "Increased interleukin-13 levels in patients with chronic heart failure," International Journal of Cardiology, vol.
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.
McKenzie, "A distinct role for interleukin-13 in Th2-cell-mediated immune responses," Current Biology, vol.
Byrd, "Secondary structure and backbone resonance assignments for human interleukin-13," Journal of Biomolecular NMR, vol.
Lipoxin A4 also discouraged type 2 innate lymphoid cells from promoting inflammation by blocking interleukin-13 secretion.
Interleukin-13 levels in serum from patients with Hodgkin disease and healthy volunteers.
IL-13R alpha2 is believed to be a naturally occurring decoy receptor, capable of binding the cytokine Interleukin-13 (IL-13), but not transmitting a signal to the inside of the cell.
Dupixent is a human monoclonal antibody that inhibits the signaling of interleukin-4 (IL-4) and interleukin-13 (IL-13), two key proteins that play a central role in type 2 inflammation that underlies specific types of asthma as well as several other allergic diseases.
The approval of dupilumab--an interleukin-4 and interleukin-13 inhibitor and the first biologic to become available for the treatment of atopic dermatitis--has revolutionized the therapy of adults with moderate to severe disease.
Interleukin-13 has been shown to be highly expressed in AD skin on immunohistochemistry and transcriptome studies, and IL-13 gene polymorphisms are associated with increased AD risk.
Atopic dermatitis; eczema; filaggrin; filaggrin null mutation; ILC2s; interleukin-13; interleukin-25; nuocytes; toll-like receptors; type 2 innate lymphoid cells
Nagai, "Interleukin-13 induces goblet cell differentiation in primary cell culture from guinea pig tracheal epithelium," American Journal of Respiratory Cell and Molecular Biology, vol.