interleukin-12


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in·ter·leu·kin-12

(in'tĕr-lū'kin),
A cytokine derived from B lymphocytes and macrophages that induces γ-interferon (IFNγ) gene expression and IL-2 in T lymphocytes and natural killer cells and down-regulates Th2 cytokines.

in·ter·leu·kin-12

(in'tĕr-lū'kin)
A cytokine derived from B lymphocytes, T lymphocytes, and macrophages that induces interferon-γ gene expression in T lymphocytes and natural killer cells.

interleukin-12

A CYTOKINE produced by T LYMPHOCYTES that inactivates natural killer cells.
References in periodicals archive ?
Trinchieri, "Proinflammatory and immunoregulatory functions of interleukin-12," International Reviews of Immunology, vol.
Parameters IL-12p40 r P value Age (days) 0.075 0.629 Total bilirubin (mg/dl) 0.198 0.089 Direct bilirubin (mg/dl) 0.114 0.33 Albumin (g/dl) -0.0285 0.469 Alanine aminotransferase (U/l) -0.02 0.865 Aspartate aminotransferase (U/l) -0.08 0.497 Alkaline phosphatase (U/l) 0.087 0.457 Gamma-glutamyl transpeptidase (U/l) -0.042 0.723 Prothrombin time (seconds) 0.224 0.053 Hemoglobin (g/dl) -0.183 0.117 White blood cells (x[10.sup.3]/[mm.sup.3]) 0.102 0.385 Platelets (x[10.sup.3]/[mm.sup.3]) -0.013 0.912 Grade of liver fibrosis -0.06 0.607 Necroinflammatory activity -0.107 0.362 BA: biliary atresia; IL-12p40: interleukin-12 p40 subunit; r: correlation coefficient.
Trinchieri, "Interleukin-12 and the regulation of innate resistance and adaptive immunity," Nature Reviews Immunology, vol.
Seder, "Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum," Infection and Immunity, vol.
Chyczewska, "Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis," Journal of Physiology and Pharmacology, vol.
Cytokine therapy of cutaneous T-cell lymphoma: Interferons, interleukin-12, and interleukin-2.
The study authors conclude: "These results may suggest a beneficial immunostimulatory effect of short-term Chlorella supplementation which enhances the [Natural Killer] cell activity and produces interferon-gamma and interleukin-12 as well as interleukin-1beta, the Th-1 cell-induced cytokines in healthy people."
Comparison of maternal serum levels of interleukin-10, interleukin-12, and interleukin-2 in normal and preeclamptic pregnancies.
With UVA, silibinin kills; with UVB, it protects, in this case by increasing cells' expression of the protein interleukin-12, which works to quickly repair damaged cells.
Schaub et al., "Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12," Critical Reviews in Immunology, vol.
The drug inhibits two inflammatory proteins called interleukin-12 and interleukin-23.
(Nasdaq:ZIOP), a biopharmaceutical company with small molecule and synthetic biology approaches to new cancer therapies, has announced the presentation of preclinical data demonstrating the significant anti-tumor activity of Interleukin-12 (IL-12) and interferon alpha (IFNα), two proteins involved in immune response to cancers, expressed in vivo utilizing a regulated gene system.