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A cytokine derived from helper T-cell lymphocytes (Th2) that inhibits γ-interferon (IFNγ) and IL-2 secretion by T-cell lymphocytes (Th1) and inhibits mononuclear cell inflammation.
IL10A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
A cytokine derived from helper T-cell lymphocytes, B-cell lymphocytes, and monocytes that inhibits interferon gamma; (IFNγ) secretion by T-cell lymphocytes and it inhibits mononuclear cell inflammation.