IRAK1

(redirected from interleukin-1 receptor-associated kinase 1)

IRAK1

A gene on chromosome Xq28 that encodes interleukin-1 receptor (IL1R)-associated kinase 1, one of two putative serine/threonine kinases which associate with IL1R after stimulation. IRAK1 is partially responsible for IL1-induced upregulation of transcription factor NF-kappa B.
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IRAK1: Interleukin-1 receptor-associated kinase 1 TLR: Toll-like receptors NF-[kappa]B: Nuclear factor-KB AP-1: Activator protein-1 JNK: c-Jun N-terminal kinase MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (a tetrazole) DTT: Dithiothreitol PI3K: Phosphoinositide 3-kinase LPS: Lipopolysaccharide PCR: Reverse transcriptase polymerase chain reaction.
Binding of IL-1[beta] to its receptor can activate interleukin-1 receptor-associated kinase 1 (IRAK1).
Messenger RNA levels of toll-like receptor 9 (TLR9) (A), myeloid differentiation primary response 88 (MYD88) (B), interleukin-1 receptor-associated kinase 1 (IRAK1) (C), tumor necrosis factor receptor-associated factor 6 (TRAF6) (D), and nuclear factor B (NF-[kappa]B) (E) in peripheral blood mononuclear cells of chronic hepatitis B virus (CHB)-infected patients and healthy controls.