IL1A

(redirected from interleukin-1 alpha)

IL1A

A gene on chromosome 2q14 that encodes a protein belonging to the IL1 family of cytokines that is multifunctional and involved in various immune responses, inflammatory processes and haematopoiesis. It is produced by monocytes and macrophages as a proprotein, proteolytically processed, released in response to cell injury and induces apoptosis.

Molecular pathology
IL1 polymorphisms are associated with rheumatoid arthritis and Alzheimer's disease.
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References in periodicals archive ?
Libby leads a research group at Harvard Medical School and the Brigham and Womens Hospital, which recently discovered a novel mechanism by which interleukin-1 alpha (IL-1?) may lead to heart attack and stroke.
A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, andinterleukin-1 receptor antagonist genes.
Neonatal tumor necrosis factor, interleukin-1 alpha, interleukin-1 beta, and interleukin-6 response to infection.
Romzova et al., "The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells," Frontiers in Immunology, vol.
Interleukin-1 alpha (IL-1[alpha]) and interleukin-1 beta (IL-1[beta]) are classified as proinflammatory cytokines.
Eiden, "Interleukin-1 alpha and tumor necrosis factor-alpha differentially regulate enkephalin, vasoactive intestinal polypeptide, neurotensin, and substance P biosynthesis in chromaffin cells," Endocrinology, vol.
According to the company, Xilonix specifically targets and neutralises interleukin-1 alpha (IL-1a), a molecule known to promote angiogenesis (the growth and spread of tumors), as well as mediate symptoms of metabolic dysregulation (loss of weight and muscle mass), fatigue and anxiety associated with advanced cancer.
Fadellah, "Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis," Saudi Medical Journal, vol.
Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.
Measurement of interleukin-1 alpha and -1 beta in gingival crevicular fluid: implications for the pathogenesis of periodontal disease.
Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production.
A physical map of the region encompassing the human interleukin-1 alpha, beta and the interleukin-1 receptor antagonist genes.