interleukin-1


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in·ter·leu·kin-·1

(in'tĕr-lū'kin),
A cytokine, derived primarily from mononuclear phagocytes, that enhances the proliferation of T-helper cells and the growth and differentiation of B cells. Il-1 induces the release of Il-2. When secreted in larger quantities, IL-1 is a mediator of inflammation, entering the bloodstream and causing fever, inducing synthesis of acute phase proteins, and initiating metabolic wasting. There are two distinct forms of IL-1:, α and β, both of which perform the same functions but represent different proteins.

interleukin-1

(ĭn′tər-lo͞o′kĭn-wŭn′)
n.
Any of a family of cytokines that are released by macrophages and other cells and stimulate the inflammatory response.

in·ter·leu·kin-1

(in'tĕr-lū'kin)
A cytokine, derived primarily from mononuclear phagocytes, which enhances the proliferation of T-helper cells and growth and differentiation of B cells.

interleukin-1

A powerful polypeptide hormone produced by MACROPHAGES and fibroblasts that acts on LYMPHOCYTES to increase their ability to respond to ANTIGENS. Interleukin-1 is also responsible for resetting the temperature regulating mechanism at a higher level and thus causing fever, for the induction of the release of ACUTE PHASE PROTEINS, and for promoting the absorption of bone by OSTEOCLASTS.

in·ter·leu·kin-1

(in'tĕr-lū'kin)
A cytokine, derived primarily from mononuclear phagocytes, which enhances the proliferation of T-helper cells and growth and differentiation of B cells.
References in periodicals archive ?
Interleukin-1 and interleukin-8 in nicotine-and lipopolysaccharide-exposed gingival keratinocyte cultures.
Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus.
Arend et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist," Nature, vol.
Studies supporting the role of Interleukin-1 in OA severity and progression have included data from animal susceptibility models, models of Interleukin-1 targeted therapy, genetic association studies, and elevated Interleukin gene expression in patients with generalised OA.
Single nucleotide polymorphisms in the human interleukin-1 B gene affect transcription according to haplotype context.
A physical map ofthe region encompassing the human interleukin-1 a, interleukin-1 [beta], and interleukin-1 receptor antagonist genes.
This brings us back to interleukin-1, an inflammatory agent found in arthritic joints that has been shown to cause cartilage degeneration.
The abstract, entitled, Pre-treatment Endogenous Interleukin-1 Receptor Antagonist (IL-1Ra) Levels in Metastatic Colorectal Cancer (mCRC) Patients are Associated with Clinical Outcomes After Anti-Interleukin-1a Therapy (MABp1), will be presented by renowned oncologist, Dr.
(3) Keratinocytes, when challenged, with bacterial infection, express a large variety of cytokines and growth factors including interleukin-1 alpha (IL-1a), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-a) and platelet-derived growth factor(PDGF).
Biopharmaceutical company Ligand Pharmaceuticals (NasdaqGM:LGND) revealed on Tuesday the launch of an exclusive global license agreement for the development and commercialisation of its Interleukin-1 Receptor Associated Kinase-4 (IRAK-4) inhibitors in partnership with TG Therapeutics (NasdaqCM:TGTX).
Like the original PST[R] test, Perio-Predict[TM] measures variations in the genes for Interleukin-1 (IL-1), a key mediator of inflammation, and identifies individuals who are at an increased risk for more severe periodontal disease.