IL4R

(redirected from interleukin 4 receptor)

IL4R

A gene on chromosome 16p12.1-p11.2 that encodes the alpha chain of the IL4 receptor, a type-I transmembrane protein which can bind IL4 and IL13 to regulate IgE production. ILR4 also binds IL4 to promote differentiation of Th2 cells.

Molecular pathology
Allelic variants in IL4R have been associated with atopy, which is accompanied by allergic rhinitis, sinusitus, asthma and eczema, as well as by Japanese cedar pollinosis.
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References in periodicals archive ?
Loughlin, "Common variants within the interleukin 4 receptor a gene (IL4R) are associated with susceptibility to osteoarthritis," Human Genetics, vol.
Interleukin 4 receptors were also significantly upregulated in both chicken lines (Supplementary Table S4, Figures 4 and 5).