IL28A

(redirected from interleukin 28A)

IL28A

A gene on chromosome 19q13.13 that encodes interleukin-28A, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28A is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
References in periodicals archive ?
SEATTLE -- Novo Nordisk Obtains Development Rights Outside North America for Interleukin 28a, 29 and 31
ZymoGenetics licensed to Novo Nordisk exclusive development rights outside North America to patents covering Interleukin 28A (IL-28A), Interleukin 29 (IL-29) and Interleukin 31 (IL-31).