IL1R1

(redirected from interleukin 1 receptor, type I)

IL1R1

A gene on chromosome 2q12 that encodes a cytokine receptor for interleukin alpha (IL1A), interleukin beta (IL1B) and interleukin 1 receptor, type I (IL1R1/IL1RA). After binding to IL1, it associates with the co-receptor IL1RAP to form the high-affinity interleukin-1 receptor complex, which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signalling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/co-receptor subunit.
References in periodicals archive ?
The effects of intravenous injection of lipopolysaccharide (LPS; 400 ng/kg) or saline (0.9% w/v NaCl) on the relative gene expression (mean [+ or -] standard error of the mean; n = 6 animals per group) of toll-like receptor (TLR) 4 (panel A), interleukin 1 receptor, type I (IL1R1; panel B), interleukin 1 receptor, type II (IL1R2; panel C), interleukin 6 receptor (IL6R; panel D), glycoprotein 130 (IL6ST, panel E), tumor necrosis factor receptor, type 1 (TNFRSF1A; panel F) and tumor necrosis factor receptor, type 2 (TNFRSF1B; panel G) in the pineal glands of ewes during the short-night (SN, May/June) and long-night (LN, November/December) photoperiods.