interim analysis


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interim analysis

The analysis of data in a clinical trial comparing intervention groups at any time before the formal completion of the trial, typically before recruitment is complete.

interim analysis

Clinical trials Analysis of early data accumulated in a clinical trial, before all of the Pts have been enrolled, to detect trends that might warrant modification of the protocol, change in type or format of data being collected or, if extreme, trial termination. See CONSENSUS II.
References in periodicals archive ?
At the time of this interim analysis, infants had been followed for up to 25.
The decision to expand the target number of enrolled patients is based on favourable interim analysis results of a Phase Ib/II study (Study 218) of eribulin in combination with pembrolizumab for metastatic triple-negative breast cancer, which is being jointly conducted by Eisai and Merck & Co.
M2 PHARMA-June 8, 2017-Bone Therapeutics completes patient recruitment for pivotal interim analysis of Phase III Osteonecrosis trial
In line with best practice for blinded Phase 3 clinical trials, the interim analysis data are only reviewed by the IDMC.
Biogen and Ionis Pharmaceuticals' Phase III study evaluating SPINRAZA (nusinersen), an investigational treatment for spinal muscular atrophy (SMA), met the primary endpoint at the interim analysis.
The primary result of the study will measure changes in insulin sensitivity in peripheral and adipose tissue over a 24-week period and will include an interim analysis at 12 weeks.
Most IRBs do not receive outcome data or have adequate statistical expertise to perform proper interim analysis to adequately weigh the risk and benefits of the trials.
Mesoblast has completed the pre-specified interim analysis performed when 50 percent of the patients had completed their six month follow-up visits.
Merck said a green light for the so-called "IMPROVE-IT" study to continue was given after the panel conducted an interim analysis of safety and efficacy trends in the study, which has enrolled nearly 17,000 patients worldwide.
The milestone payment is based on the previously announced positive review of the scheduled interim analysis of the company's pivotal phase II/III Canadian and European trial (MAESTRO-01) of dirucotide (MBP8298) in patients with secondary progressive MS.
the Men's Health Biotech Company, has announced the results of a lipid interim analysis of the pivotal Phase III ADT clinical trial evaluating oral, once daily ACAPODENE(R) (toremifene citrate) 80mg for the treatment of the multiple serious side effects of androgen deprivation therapy (ADT) in men with advanced prostate cancer.
The recommendation came after the interim analysis of a safety study suggested that salmeterol may be tied to an increased risk of asthma-related deaths ox life-threatening asthma episodes.

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