suppressor mutation

(redirected from intergenic suppression)
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mutation

 [mu-ta´shun]
1. a permanent transmissible change in the genetic material.
2. an individual exhibiting such a change.
point mutation a mutation resulting from a change in a single base pair in the DNA molecule.
somatic mutation a genetic mutation occurring in a somatic cell, providing the basis for mosaicism.
suppressor mutation the correction of the effect of a mutation at one locus by a mutation at another locus.

sup·pres·sor mu·ta·tion

1. a second mutation that alters the anticodon in a tRNA so that it can recognize a nonsense (stop) codon, thus suppressing termination of the amino acid chain. Compare: amber mutation, ochre mutation, umber mutation.
2. genetic changes such that the effect of a m. in one place can be masked by a second m. in another location. There are two types: intergenic suppression (occurring in a different gene) and intragenic suppression (occurring in the same gene but at a different site).
Synonym(s): nonsense mutation

sup·pres·sor mu·ta·tion

(sŭ-pres'ŏr myū-tā'shŭn)
1. A mutation that alters the anticodon in a tRNA so that it is complementary to a termination codon, thus suppressing termination of the amino acid chain.
2. Genetic changes such that the effect of a mutation in one place can be overcome by a second mutation in another location. There are two types: intergenic suppression (occurring in a different gene) and intragenic suppression (occurring in the same gene but at a different site).

suppressor mutation

a MUTATION that acts to restore the normal functioning of another gene located elsewhere in the GENOME (intergenic suppression), or another mutation at a different site in the same gene (intragenic suppression).