IFITM1(redirected from interferon-inducible protein 9-27)
IFITM1A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM1 downregulates IFN-gamma by inhibiting ERK activation, or by arresting p53-dependent cell growth in G1.
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