Interferon-induced transmembrane protein 3 | definition of interferon-induced transmembrane protein 3 by Medical dictionary
IFITM3 (redirected from interferon-induced transmembrane protein 3)
IFITM3 A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication.
IFITM3 mutations are linked to increased susceptibility to viral infections.
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References in periodicals archive
Investigators have now shown that reducing levels of one antiviral factor called interferon-induced transmembrane protein 3
(IFITM3) makes cultured cells highly sensitive to ZIKV infection.
Hang, "S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3
(IFITM3)-mediated resistance to influenza virus," Journal of Biological Chemistry, vol.