interferon-alpha


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interferon-alpha

IFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS, HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;12 of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors.
References in periodicals archive ?
Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature.
Viral interaction and responses in chronic hepatitis C and B coinfected patients with interferon-alpha plus ribavirin combination therapy.
Ischemic colitis during pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
Tomer, "The clinical and physiological spectrum of interferon-alpha induced thyroiditis: Toward a new classification," Hepatology, vol.
Poor sleep quality before fore interferon-alpha treatment appeared to predict depression.
Survival for sunitinib patients given no further treatment after they stopped taking the drug was 28.1 months compared with 14.1 months for those on interferon-alpha (IFN alpha).
The in vivo and in vitro effects of chicken interferon-alpha on infectious bursal disease virus and Newcastle disease infection.
Wyeth said the drug is the first targeted renal cancer therapy proven to extend median overall survival versus interferon-alpha, an active comparator, in patients with advanced kidney cancer.
MEDI-545 (previously known as MDX-1103) is a fully human monoclonal antibody targeting interferon-alpha. Published data indicate that levels of interferon-alpha are elevated in many patients with active systemic lupus erythematosus (SLE, or lupus) and other autoimmune disorders, and may be associated with disease activity.
In a five-year follow-up of a phase III, multicenter study, 1,106 patients newly diagnosed with CML were randomized into groups receiving daily oral imatinib or a combination of interferon-alpha plus cytarabine.

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