Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
interferon-alphaIFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS, HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;1⁄2 of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.