interferon-alpha


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interferon-alpha

IFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS, HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;1⁄2 of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature.
FREQUENCY OF THYROID DYSFUNCTION DURING TFT IN INTERFERON AND RIBAVIRIN THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C
Viral interaction and responses in chronic hepatitis C and B coinfected patients with interferon-alpha plus ribavirin combination therapy.
How to turn 8 pennies into $600
Ischemic colitis during pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
Treatment of hepatitis C virus infection and associated vascular complications: a literature review
Tomer, "The clinical and physiological spectrum of interferon-alpha induced thyroiditis: Toward a new classification," Hepatology, vol.
Autoimmune and neoplastic thyroid diseases associated with hepatitis C chronic infection
Poor sleep quality before fore interferon-alpha treatment appeared to predict depression.
Poor sleep may predict major depression risk
Survival for sunitinib patients given no further treatment after they stopped taking the drug was 28.1 months compared with 14.1 months for those on interferon-alpha (IFN alpha).
Kidney cancer pill offers new hope
Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus.
Interferon-alpha treatment in patients with chronic viral hepatitis c: the incidence of major depression and changes in quality of life/ Kronik hepatit c'li hastalarda interferon-alfa tedavisi: major depresyonun insidansi ve yasam kalitesinde degisiklikler
Patients who took other treatments, such as thalidomide and interferon-alpha, had no higher risk, researchers said.
Amgen Inc (Thousand Oaks CA) and Johnson & Johnson's (New Brunswick NJ) anemia drugs may raise the risk that patients with a bone marrow disease will later develop leukemia, according to an analysis of 30 years of patient records
The in vivo and in vitro effects of chicken interferon-alpha on infectious bursal disease virus and Newcastle disease infection.
Super-sentinel chickens and detection of low-pathogenicity influenza virus
Wyeth said the drug is the first targeted renal cancer therapy proven to extend median overall survival versus interferon-alpha, an active comparator, in patients with advanced kidney cancer.
FDA approves Wyeth Pharmaceutical's Torisel for treatment of advanced kidney cancer
MEDI-545 (previously known as MDX-1103) is a fully human monoclonal antibody targeting interferon-alpha. Published data indicate that levels of interferon-alpha are elevated in many patients with active systemic lupus erythematosus (SLE, or lupus) and other autoimmune disorders, and may be associated with disease activity.
MEDIMMUNE STARTS PHASE I TRIAL FOR PSORIASIS TREATMENT
In a five-year follow-up of a phase III, multicenter study, 1,106 patients newly diagnosed with CML were randomized into groups receiving daily oral imatinib or a combination of interferon-alpha plus cytarabine.
Imatinib effective against newly diagnosed myeloid leukemia

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