interferon-alpha


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

interferon-alpha

cell-signaling glycoprotein (cytokine) produced by virus-induced lymphocyte cultures. It provides antiviral activity and activation of natural killer cells and is used to treat several types of neoplasms. Also spelled interferon-alfa.

interferon-alpha

IFN-α Immunology A family of 20 leukocyte-derived immunomodulating glycoproteins with antiproliferative and antiviral activity Indications Recombinant IFN-α is used to treat hairy cell leukemia, CML, KS, HPV-related proliferations–eg, condyloma acuminatum, respiratory papillomatosis, pulmonary hemangioendotheliosis, chronic hepatitis–eg, HCV, as well as renal CA ±vinblastine, NHL, and to inhibit angiogenesis Side effects Flu-like Sx, malaise, fatigue, headache, anxiety, vertigo, depression, ↑ aminotransferase, BM suppression–granulocyte toxicity, SVT with hypotension or HTN, potentially fatal CHF, exacerbation of multiple sclerosis;12 of Pts, especially with cirrhosis and hypersplenism don't tolerate therapy because of fatigue, profound thrombocytopenia and neutropenia. See Angiogenesis inhibitors.
References in periodicals archive ?
Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature.
Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C.
All patients enrolled in the trial are null responders, which is defined as patients who have failed to achieve a 2 log10 reduction in viral load during previous 12 to 24 weeks of treatment with pegylated recombinant interferon-alpha plus ribavirin, the current standard of care treatment.
Thyroid autoantibodies and thyriod dysfunction during treatment with interferon-alpha for chronic hepatitis C.
Since activation of T cells predicts the progression of HIV-1 infection to AIDS, the researchers found that stimulation of pDCs in response to HIV-1 led to the subsequent activation of CD8+ T cells by means of interferon-alpha secretion.
Acute effects of interferon-alpha administration on thyroid hormone metabolism in health men.
The data show that IMO-2125 induced high levels of endogenous interferon-alpha along with interferon-beta, interferon-lambda, and other proteins including IP-10 and 2'-5'-OAS.
We never considered that interferon-alpha could be a major player in early type-1 diabetes," said Qing Li, MD, PhD, a postdoctoral scholar in microbiology and immunology who was the primary author of a paper describing the new result.
These data suggest that IFN-alpha-XL may provide patients with a more tolerable regimen that has potentially better efficacy compared with existing interferon-alpha based therapies.
Anderson has successfully used bone marrow-derived stem cells to transport anti-tumor proteins, such as interferon-beta (IFN-[eth]) and interferon-alpha (IFN-[eth]), to a tumor site in animal models.
The current standard of care therapy is interferon-alpha (IFN-a) given in conjunction with ribavirin, with nearly identical products marketed by Roche Pharmaceuticals and Schering Plough.
As a result of Pestka's ability to isolate, purify and clone interferons, he produced recombinant interferon-alpha for clinical trials nearly a full year before anyone else.

Full browser ?