Koppelman et al., "Evidence of association between Interferon Regulatory Factor 5 gene polymorphisms and asthma," Gene, vol.
Recently, we identified the transcription factor interferon regulatory factor 5 (IRF5) as the major regulator of proinflammatory M1 macrophage polarisation .
Guedj et al., "The Interferon Regulatory Factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype," Annals of the Rheumatic Diseases, vol.
Several lines of evidence implicate the interferon pathway in SLE pathogenesis, and thus the report in 2005 by Sigurdsson and coworkers (32) of genetic association with the interferon regulatory factor 5 (IRF5) gene among Swedish and Finnish SLE cases and controls quickly led to attempts at replication in other populations.
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Interferon regulatory factor 5 is a common susceptibility gene to different autoimmune disorders.
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
Koppelman et al., "Evidence of association between interferon regulatory factor 5
polymorphisms and asthma," Gene Gene, vol.
Eloranta et al., "Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5
expression in blood cells of patients with systemic lupus erythematosus," Arthritis and Rheumatism, vol.
Variants of interferon regulatory factor 5
are associated with neither neuromyelitis optica nor multiple sclerosis in the Southeastern Han Chinese population.
Interferon regulatory factor 5 (IRF-5) is a member of the IRF family of transcription factors that induces the expression of type I IFN and IFN-inducible genes [28-30].
Abbreviations Ct: Cycle threshold H&E: Hematoxylin and eosin IFN: Interferon IL: Interleukin IRF-5: Interferon regulatory factor 5 ISG15: IFN[alpha]-inducible protein (clone IFI-15K) LN: Lupus nephritis LY6E: Lymphocyte antigen 6 complex locus E MCP-1: Monocyte chemotactic protein 1 TWEAK: Tumor necrosis factor-like weak inducer of apoptosis OASL: 2', 5'-Oligoadenylate synthetase-like PAS: Periodic acid-Schiff PBMCs: Peripheral blood mononuclear cells rhTWEAK: Recombinant human TWEAK SLE: Systemic lupus erythematosus TLR: Toll-like receptors.