interferon gamma


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Related to interferon gamma: interferon alpha

in·ter·fer·on gam·ma

interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation; only one gene codes for gamma interferon. interferon γ behaves like a biologic response modifies and is highly immunoregulatory.

interferon gamma

interferon gamma

a small, species-specific glycoprotein produced by mitogen-stimulated T cells. It possesses antiviral activity and plays a central role in the immunoregulatory processes.

IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.

interferon gamma

IFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, activates monocyte cytotoxicity and enhances NK cell activity; IFN-γ is ↓ in IgA deficiency, lymphoma, CLL, infections–eg, CMV, EBV, rubella, lepromatous leprosy, TB, SLE, rheumatoid arthritis, sickle cell anemia, post-transplantation Indications Recombinant IFN-γ is used to treat condylomata acuminata, CLL, Hodgkin's disease, mycosis fungoides, rheumatoid arthritis, and possibly leprosy, TB, nontuberculous mycobacterial infections, toxoplasmosis, chronic granulomatous disease–to prevent infections; IFN-γ suppresses collagen synthesis by fibroblasts, ↓ the size of keloids, causing a local ↑ in inflammatory cells and mucin production, and may be of use in controlling abnormal fibrosing conditions Side effects Acute renal failure, rash, headache, chills

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
That interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
Synonym(s): antigen interferon, immune interferon.

interferon gamma

An INTERFERON used as an antiviral drug. A brand name is Immukin.

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
References in periodicals archive ?
Cells such as epithelial and endothelial cells were found to respond to interferon gamma by producing an enzyme, indolelamine-2-3-dioxygenase (IDO), that converts the amino acid tryptophan to products called kynurenines.
The interferon gamma assay currently in use measures a chemical messenger produced by white blood cells fighting TB and other infections.
Findings showed that both concentrations of fluoxetine significantly lowered production of interferon gamma (IFN-[gamma]), while imipramine and venlafaxine had no effect.
Tenders are invited for Mycobacterium Tuberculosis (TB) Interferon Gamma Release Assays System (IGRA) for HCHD.
Actimmune is reportedly a synthesized version of interferon gamma, a naturally occurring protein believed to stimulate the immune system.
The cross-sectional study involved 2,017 military recruits at Fort Jackson, South Carolina, who completed a risk factor questionnaire and underwent testing with the three tests: 1) tuberculin skin test (TST); 2) the interferon gamma release assays (IGRAs) QuantiFERON[R]-TB Gold In-Tube test (QFT-GIT); and 3) the TSPOF TB test (T-Spot).
Previous evidence indicated that interferon gamma suppresses symptoms by preventing re-emergence of herpes virus, which lurks in the nervous system.
Among the many agents that have been used are pentavalent antimonials (which cause some systemic toxicity and are used to treat the mucocutaneous form), pentamidine, amphotericin B (which is used primarily for visceral leishmaniasis), paromomycin (used for the visceral and cutaneous forms), cytokines such as interferon gamma (used for some mucocutaneous forms, including those caused by Leishmania braziliensis strains), oral antifungals such as ketoconazole, fluconazole, and itraconazole (which are well tolerated), and hipoxanthine (which inhibits purine anabolism and slows Leishmania proliferation).
With the help of Mondobiotech, whose groundbreaking work and expertise led to the development of Interferon gamma for IPF, we are planning to expand the potential indications for Actimmune to asthma, one of the largest unmet needs in pulmonary medicine.
Corradin and his colleagues also tested eight of the volunteers for interferon gamma, a protein made by T cells that orchestrates immune responses.

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