interferon beta


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Related to interferon beta: Interferon gamma, interferon beta 1b

in·ter·fer·on be·ta

interferon elaborated by fibroblasts and microphages in response to the same stimuli as interferon alpha; only one gene codes for this interferon.

interferon beta

interferon beta

Fibroblast interferon IFN-β A 20 kD anti-viral protein with 30% 'homology' with IFN alpha, encoded on chromosome 9, produced by fibroblasts in response to viruses or polyribonucleotides

interferon beta

A INTERFERON used as a drug to reduce the severity, and frequency of relapses, of MULTIPLE SCLEROSIS. Unfortunately, there is little clear evidence that this interferon can affect the long-term outcome. In addition, it may cause an influenza-like effect for several months after starting treatment. Brand names are Avonex and Betaferon.

in·ter·fer·on be·ta

(intĕr-fēron bātă)
Interferon elaborated by fibroblasts and microphages.
References in periodicals archive ?
A new randomised long-term trial of azathioprine, interferon beta and glatiramer would probably cost less than the current scheme as only a third of people would get the most expensive drug.
In spite of the positive safety profile of both interferon beta and glatiramer acetate, the need for frequent dosing and patients' difficulty in adhering to prescribed dosing schedules may limit the therapeutic efficacy of these drugs (Reynolds, Stephen, Seaman, & Rajagopalan, 2010; Wong, Gomes, Mamdani, Manno, & O'Connor, 2011).
Currently, there are 10 Food and Drug Administration (FDA)-approved treatments for MS, including four interferon beta preparations, glatiramer acetate, natalizumab, fingolimod, mitoxantrone, teriflunomide, and dimethyl fumarate (DMF; Table 2).
AZD9412 is a novel inhaled interferon beta therapy, which is being developed to support the immune system by correcting a deficiency that makes it vulnerable to respiratory tract viral infections.
The company expects to start pivotal testing in 2012 after the multiple ascending dose (MAD) trial demonstrated the potential for monthly treatment and suggested the increased tolerability of AZ01, a long-acting interferon beta, compared to other treatment options.
Fingolimod 0.5 mg reduced the rate of brain atrophy, or brain volume loss, compared to interferon beta 1a IM over 12 months, irrespective of disease activity prior to study start as shown in an analysis of the pivotal Phase III TRANSFORMS study.
Today, Betaseron and Avonex (forms of interferon beta) are proven to "modify" MS.

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