interferon alpha

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in·ter·fer·on al·pha

the major interferon made by virus-induced leukocytes; several different subtypes exist that are elaborated by leukocytes in response to viral infection or to stimulation with double-stranded RNA. There are 14 genes on the short arm of chromosome 9 that code for these substances in humans. IFN-α-2A and -2B are protein products made by recombinant DNA techniques and are used as antineoplastic agents.

Synonym(s): leukocyte interferon

Farlex Partner Medical Dictionary © Farlex 2012

interferon alpha

See alpha interferon.

Interferon alpha

Potent immune-defense protein; used as an anti-cancer drug.

Mentioned in: Waldenström's Macroglobulinemia

in·ter·fer·on al·pha

(intĕr-fēron alfă)

The major interferon made by virus-induced leukocytes; several subtypes exist that are elaborated by leukocytes in response to viral stimulation.

Medical Dictionary for the Dental Professions © Farlex 2012

References in periodicals archive ?

Keywords: Hepatitis C virus, Hepatitis B virus, Interferon alpha receptor 1, Interferon alpha receptor 2, Interferon therapy response, Signal transducer and activator of transcription1.

Interferon alpha receptors and STAT1 as therapy predictors of a sustained virological response in hepatitis C/B co-infection

A strategy for high-level expression of soluble and functional human interferon alpha as a GST-fusion protein in E.

Soluble Expression of IFN[alpha]2-T[alpha]1 Fusion Protein in Escherichia coli by N-terminal SUMO Fusion and its Anti-Proliferative Activity

Despite the development of thyroid disorders (overt and sub-clinical), patients completed their antiviral therapy with Interferon alpha and ribavirin.

FREQUENCY OF THYROID DYSFUNCTION DURING TFT IN INTERFERON AND RIBAVIRIN THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C

Cytokine and Psychopathology: lessons from interferon alpha. Biol Psychiatry 2004; 56: 819-24.

PRE-TREATMENT ANXIETY AND INTERFERON INDUCED DEPRESSION IN HEPATITIS C PATIENTS

[Pericarditis secondary to interferon alpha in chronic hepatitis C].

Treatment of hepatitis C virus infection and associated vascular complications: a literature review

Pericardial effusion and tamponade following interferon alpha treatment for locally advanced melanoma.

Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review

Caption: The lethal Ebola virus (shown in a false-color micrograph) appears susceptible to a combination treatment of antibodies and the antiviral protein interferon alpha delivered by an inactivated virus, a study in monkeys shows.

Hopes raised for Ebola treatment: monkeys given dual therapy survive lethal viral infection

Poole, "Interferon alpha in systemic lupus erythematosus," Journal of Biomedicine and Biotechnology, vol.

Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus

Methods: This was a quasi - experimental study in which patients of both sexes between ages 20 - 49 were randomly allocated to receive three different formulations of interferon alpha 2b in three groups, I, II, and III, after giving them first dose of three million units of interferon alpha 2b sub-cutaneously.

FIRST DOSE RESPONSE OF TREATMENT OF THREE FORMULATIONS OF INTERFERON ALFA IN PATIENTS USING LIMITED SAMPLING STRATEGY

[10] Retnoningrum, D.S., "et al", 2010, "Construction of synthetic open reading frame encoding human interferon alpha 2b for high expression in Escherichia coli and characterization of its gene product," J.

Enhanced biological activity of recombinant human interferon alpha produced in Pichia pastoris using a codon-optimized synthetic cDNA

One month before, the FDA had approved sorafenib (brand name Nexavar) in patients with RCC in whom previous therapy (usually cytokines such as interferon alpha or interleukin-2) had failed.

Renal cell carcinoma: molecularly targeted therapy

Contrast echocardiography may be a useful non-invasive technique for detecting PAVM and the interferon alpha may be first treatment option for patients with IHHE and PAVM.

Successful treatment of pulmonary arteriovenous malformation and infantile hepatic hemangioendothelioma with alpha-interferon/Infantil hepatik hemanjiyoendotelyoma ve pulmoner arteriyovenoz malformasyonun alfa-interferon ile basarili bicimde tedavisi