interferon alfa-2b


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Related to interferon alfa-2b: interferon alpha, interferon alfa-2a, Intron A

interferon

 [in″ter-fēr´on]
any of a family of glycoprotein biological response modifiers used as antineoplastic agents and immunoregulators; they inhibit cellular growth, alter the state of cellular differentiation, have effects on the cell cycle, interfere with oncogene expression, alter cell surface antigen expression, have effects on antibody production, and regulate cytotoxic effector cells.
interferon-α the major interferon produced by virus-induced leukocyte cultures; its primary producer cells are null cells, and its major activities are antiviral activity and activation of NK cells.
interferon alfa-2a a synthetic form of interferon-α produced by recombinant technology that acts as a biologic response modifier, used as an antineoplastic in the treatment of hairy cell leukemia and AIDS-related Kaposi's sarcoma; administered intramuscularly or subcutaneously.
interferon alfa-2b a synthetic form of interferon-α produced by recombinant technology that acts as a biologic response modifier, used in the treatment of veneral warts, hepatitis B, and chronic hepatitis C and as an antineoplastic in the treatment of hairy cell leukemia, malignant melanoma, non-Hodgkin's lymphomas, multiple myeloma, mycosis fungoides, and AIDS-related Kaposi's sarcoma; administered intramuscularly, subcutaneously, or intralesionally.
interferon alfacon-1 a synthetic interferon related to both α and β interferons, produced by recombinant DNA technology; used in the treatment of chronic hepatitis C virus infection, administered subcutaneously.
interferon alfa-n3 a highly purified mixture of natural human interferon proteins that acts as a biologic response modifier; used in the treatment of venereal warts, administered intralesionally.
interferon-β the major interferon produced by double-stranded RNA-induced fibroblast cultures; the major producer cells are fibroblasts, epithelial cells, and macrophages, and its major activity is antiviral.
interferon beta-1a a synthetic form of interferon-β produced by recombinant DNA techniques that acts as a biologic response modifier; used in the treatment of relapsing forms of multiple sclerosis; administered intramuscularly.
interferon beta-1b a synthetic modified form of interferon-β produced by recombinant DNA techniques; used as a biologic response modifier in the treatment of relapsing forms of multiple sclerosis; administered subcutaneously.
interferon-γ the major interferon produced by lymphocyte cultures that have been immunologically stimulated by mitogens or antigens; the major producer cells are T lymphocytes, and its major activity is immunoregulation.
interferon gamma-1b a synthetic form of interferon-γ produced by recombinant technology that acts as a biologic response modifier and antineoplastic. It is used to reduce the frequency and severity of serious infections associated with chronic granulomatous disease, administered subcutaneously.

interferon alfa-2b

n.
A synthetic form of interferon alpha produced by recombinant DNA technology, used in the treatment of chronic hepatitis B and C, hairy cell leukemia, malignant melanoma, follicular lymphoma, genital warts, and AIDS-related Kaposi's sarcoma.

interferon alfa-2b

a synthetic form of interferon-α produced by recombinant technology that acts as a biological response modifier, used in the treatment of venereal warts, hepatitis B, chronic hepatitis C, and as an antineoplastic in the treatment of hairy cell leukemia, malignant melanoma, non-Hodgkin's lymphomas, multiple myeloma, mycosis fungoides, and AIDS-related Kaposi's sarcoma. It is administered intramuscularly, subcutaneously, or intralesionally.

interferon alfa-2b, recombinant

a parenteral antineoplastic drug with indications, contraindications, and adverse effects similar to those of interferon alfa-2a, recombinant.
References in periodicals archive ?
Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients.
Interferon alfa-2b (Intron A) comes in a vial containing 10 million units with 1 mL of diluent.
Table 2 Drugs for the Treatment of Chronic Hepatitis C Immunomodulators Interferon alfa-2a (Roferon[R], Roche Pharmaceuticals) interferon alfa-2b (Intron A[R], Schering Corporation) Interferon alfacon-1 (Infergen[R], Valeant Pharmaceuticals) Peginterferon alfa-2a (Pegasys[R], Roche Pharmaceuticals) Peginterferon alfa-2b (PegIntron[R], Schering Corporation) Antiviral Ribavirin (Copegus, Rebetol, Ribasphere, and other manufacturers) Drugs Currently in Advanced Stages of Development * Albinterferon alfa-2b (Albuferon[R], Human Genome Sciences, Inc.
Three drugs, interferon alfa-2b, lamivudine, and adefovir dipivoxil, have been FDA-approved as an effective therapy for HBV.
The interferon alfa agents include interferon alfa-2a (Roferon-A), peginterferon alfa-2a (Pegasys), interferon alfa-2b (Intron A), peginterferon alfa-2b (Peg-Intron), interferon alfacon-1 (Infergen), and interferon alfa-n3 (Alferon N).
Rebetol is indicated for combination therapy with interferon alfa-2b in patients aged 3 years and older with chronic hepatitis C and compensated liver disease previously untreated with interferon-[alpha].
The study will assess whether rapid and aggressive treatment with interferon alfa-2b can prevent severe neurologic sequelae or death in such patients, said Dr.
Ribavirin is marketed in combination with Schering-Plough's interferon alfa-2b product (Rebetron(TM)) and with pegylated interferon alfa-2b (PEG-Intron(R) - Rebetol(R))
The drug treatment - a combination of pegylated interferon alfa-2b and ribavirin - has been shown to slow the progression of hepatitis C.
Fried, MD, of the University of North Carolina, Chapel Hill, and colleagues found a higher sustained viral response rate among HCV patients treated with this combination of drugs than with the current standard therapy, interferon alfa-2b plus ribavirin (Rebetron), said a Medscape Wire article.
Patients with melanoma and a single tumor-positive sentinel lymph node had no improvement in overall or disease-free survival with adjuvant high-dose interferon alfa-2b, a study showed.
Peginterferon alfa-2b plus riba-virin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial.