interferon alfa-2a


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to interferon alfa-2a: interferon alfa-2b, Roferon

interferon

 [in″ter-fēr´on]
any of a family of glycoprotein biological response modifiers used as antineoplastic agents and immunoregulators; they inhibit cellular growth, alter the state of cellular differentiation, have effects on the cell cycle, interfere with oncogene expression, alter cell surface antigen expression, have effects on antibody production, and regulate cytotoxic effector cells.
interferon-α the major interferon produced by virus-induced leukocyte cultures; its primary producer cells are null cells, and its major activities are antiviral activity and activation of NK cells.
interferon alfa-2a a synthetic form of interferon-α produced by recombinant technology that acts as a biologic response modifier, used as an antineoplastic in the treatment of hairy cell leukemia and AIDS-related Kaposi's sarcoma; administered intramuscularly or subcutaneously.
interferon alfa-2b a synthetic form of interferon-α produced by recombinant technology that acts as a biologic response modifier, used in the treatment of veneral warts, hepatitis B, and chronic hepatitis C and as an antineoplastic in the treatment of hairy cell leukemia, malignant melanoma, non-Hodgkin's lymphomas, multiple myeloma, mycosis fungoides, and AIDS-related Kaposi's sarcoma; administered intramuscularly, subcutaneously, or intralesionally.
interferon alfacon-1 a synthetic interferon related to both α and β interferons, produced by recombinant DNA technology; used in the treatment of chronic hepatitis C virus infection, administered subcutaneously.
interferon alfa-n3 a highly purified mixture of natural human interferon proteins that acts as a biologic response modifier; used in the treatment of venereal warts, administered intralesionally.
interferon-β the major interferon produced by double-stranded RNA-induced fibroblast cultures; the major producer cells are fibroblasts, epithelial cells, and macrophages, and its major activity is antiviral.
interferon beta-1a a synthetic form of interferon-β produced by recombinant DNA techniques that acts as a biologic response modifier; used in the treatment of relapsing forms of multiple sclerosis; administered intramuscularly.
interferon beta-1b a synthetic modified form of interferon-β produced by recombinant DNA techniques; used as a biologic response modifier in the treatment of relapsing forms of multiple sclerosis; administered subcutaneously.
interferon-γ the major interferon produced by lymphocyte cultures that have been immunologically stimulated by mitogens or antigens; the major producer cells are T lymphocytes, and its major activity is immunoregulation.
interferon gamma-1b a synthetic form of interferon-γ produced by recombinant technology that acts as a biologic response modifier and antineoplastic. It is used to reduce the frequency and severity of serious infections associated with chronic granulomatous disease, administered subcutaneously.

interferon alfa-2a

(ăl′fə-)
n.
A synthetic form of interferon alpha produced by recombinant DNA technology, used in the treatment of chronic hepatitis C, hairy cell leukemia, and certain types of chronic myelogenous leukemia.
References in periodicals archive ?
The local production of Pegylated Interferon alfa-2a (Unipeg) was made possible as a result of a sizable investment in research and development.
Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer.
Pegylated interferon alfa-2b or pegylated interferon alfa-2a in combination with ribavirin is the standard treatment for HCV infection, achieving response rates of 40% to 60% for patients with HCV genotype 1, (32) and higher rates for those with HCV genotypes 2 and 3.
Peginterferon Alfa-2a plus Ribavirin versus Interferon Alfa-2a plus Ribavirfin for Chronic Hepatitis C in HIV-Coinfected Persons.
The interferon alfa agents include interferon alfa-2a (Roferon-A), peginterferon alfa-2a (Pegasys), interferon alfa-2b (Intron A), peginterferon alfa-2b (Peg-Intron), interferon alfacon-1 (Infergen), and interferon alfa-n3 (Alferon N).
ZADAXIN is currently in a phase 3 program in the United States in combination with Pegasys, pegylated interferon alfa-2a, for the treatment of hepatitis C, in a phase 2 program in combination with lamivudine for the treatment of hepatitis B and in two phase 2 trials for the treatment of liver cancer.
Combination therapy with pegylated interferon alfa-2a (Pegasys) and the oral antiviral medication ribavirin is being touted as an alternative to standard treatment for Hepatitis C, according to findings released at the May Digestive Disease Week 2001 conference in Atlanta.
* Interferon Alfa-2a (Roferon-A), Schering-Plough Approved November 21, 1988 for the treatment of AIDS-related Kaposi's sarcoma in selected patients.
Pegylated interferon alfa-2a plus ribavirin versus pegylated interferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C in HIV-infected patients.
Efficacy of direct-acting antiviral regimens involving the protease inhibitors telaprevir (Incivek) and boceprevir (Victrelis) combined with pegylated interferon alfa-2a or -2b in combination with ribavirin (PEG-IFN/RBV) in cirrhotic nonresponders to prior therapy was good, but safety was "poor," said Dr.
Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma.
The clinical trial is a Phase IIa, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and antiviral activity of oral ACH-1625 in combination with pegylated interferon alfa-2a and ribavirin after 28 days of dosing and after 12 weeks of dosing in subjects with chronic hepatitis C virus genotype 1.