(15) Prominent intercellular bridges
(spongiosis or acantholysis) and superficial premature cells with eosinophilic cytoplasm can also be appreciated.
Abnormal mitotic figures and the intercellular bridges
are less conspicuous.
They lack discrete cytoplasmic borders, real keratinization or discernible intercellular bridges
, unlike real squamous metaplasia which is a rare finding in gallbladders.
Hematoxylin-eosin staining showed cytoplasm-abundant tumor cells connected by intercellular bridges
. Keratinization was not clear (Figure 2(a)).
Similar to classic BD, pagetoid BD always shows full-level involvement of the epidermis, scattered multinucleated tumor giant cells, keratohyalin granules, single-cell keratinization, and intercellular bridges
visible between pagetoid cells, while EMPD lesion contains pagetoid cells well demarcated from nearby epidermal cells, flattened basal layer, stratum corneum involved, acinar structures, and no intercellular bridge
Histopathological examination (Figure 3) showed stained with eosin and haematoxylin showing concentric calcified rings, polygonal cell and intercellular bridges
. A final diagnosis of central calcifying epithelial odontogenic tumour was considered.
Tumor is composed of squamous cells with individual cell keratinization (white arrow) and intercellular bridges
(black arrows) (b).
Fraser, "Intercellular bridges
in vertebrate gastrulation," PLoS One, vol.
The histopathological hallmark of the classic pattern is sheets of polyhedral epithelial cells with well-defined borders and prominent intercellular bridges
. Amyloid-like substances and calcified concentric Liesegang's rings are the most classic findings.
In acanthomatous type the central area of follicles often undergo squamous metaplasia with the development of intercellular bridges
Squamous cell carcinoma (SCC) is a malignant neo- plasm of epithelial cells exhibiting squamous differentiation as characterised by the formation of kera- tin and the presence of intercellular bridges
.1 These squamous cells form the lining epithelium of skin, oral cavity, oesophagus, rectum, vagina etc.
and single cell keratinisation were present at some foci.