Similar to classic BD, pagetoid BD always shows full-level involvement of the epidermis, scattered multinucleated tumor giant cells, keratohyalin granules, single-cell keratinization, and intercellular bridges
visible between pagetoid cells, while EMPD lesion contains pagetoid cells well demarcated from nearby epidermal cells, flattened basal layer, stratum corneum involved, acinar structures, and no intercellular bridge
Histopathological examination (Figure 3) showed stained with eosin and haematoxylin showing concentric calcified rings, polygonal cell and intercellular bridges
Careful inspection for carcinoma in situ, tumor connection with the epidermis, intercellular bridges
, or signs of keratinization should be done in all cases.
The histopathological hallmark of the classic pattern is sheets of polyhedral epithelial cells with well-defined borders and prominent intercellular bridges
Squamous cell carcinoma (SCC) is a malignant neoplasm of epithelial cells exhibiting squamous differ- entiation as characterized by the formation of keratin and the presence of intercellular bridges
In acanthomatous type the central area of follicles often undergo squamous metaplasia with the development of intercellular bridges
Squamous cell carcinoma (SCC) is a malignant neo- plasm of epithelial cells exhibiting squamous differentiation as characterised by the formation of kera- tin and the presence of intercellular bridges
and single cell keratinisation were present at some foci.
The tumour consists of sheets of uniform small cuboidal cells connected by intercellular bridges
, with intervening secretion filled narrow ductal lumina lined by eosinophilic cuticle (Fig2).
In this species, some diplotenic cells appear in pairs, maybe due to specific characteristics of the intercellular bridges
6) A definite squamous differentiation with intercellular bridges
has been identified in several cases.