ICAM1

(redirected from intercellular adhesion molecule 1)

ICAM1

A gene on chromosome 19p13.3-p13.2 that encodes a cell surface glycoprotein expressed on endothelial cells and cells of the immune system. It binds to integrins CD11a/CD18 or CD11b/CD18, and serves as a cell receptor for rhinoviruses.
References in periodicals archive ?
Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy.
Intercellular adhesion molecule 1 (ICAM-1) [9] is an endothelial adhesion molecule that stimulates leukocyte adhesion and transmigration into the vascular subendothelial space (1).
Serum soluble intercellular adhesion molecule 1 (sICAM-1) and high sensitivity C-reactive protein (hsCRP) concentrations were measured in duplicate in all subjects using enzyme-linked immunosorbent assay (ELISA) kit purchased from [Quantikine (R & D Systems Europe, Ltd.
Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen1/ intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis , Infect Immun, 62: 5205-12.
Low 25-hydroxyvitamin D levels were significantly correlated with variables of inflammation (C-reactive protein and interleukin 6 levels), oxidative burden (serum phospholipid and glutathione levels), and cell adhesion (vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 levels).
Treatment of inflammatory diseases with a monoclonal antibody to intercellular adhesion molecule 1.
In this study, an antisense compound containing uniform methoxyethoxy modifications was targeted to the 5'-cap position on the mRNA or transcript of intercellular adhesion molecule 1 (ICAM-1).
Circulating inflammatory biomarkers such as CRP, IL-6, TNF-[alpha], monocyte chemotactic protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), and E-selectin have been associated with a variety of metabolic disorders and associated outcomes (Goldberg 2009).
ISIS 2302, an antisense drug designed to inhibit production of Intercellular Adhesion Molecule 1 (ICAM-1), has completed Phase I trials and plans are under way to initiate Phase II trials in the second half of 1995 in five indications: rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's Disease, and organ transplant rejection.
In that study, we evaluated a panel of 12 vascular biomarkers that included lipid fractions and apolipoproteins, homocysteine, lipoprotein(a), and 4 inflammatory biomarkers [hsCRP, soluble intercellular adhesion molecule 1 (sICAM-1), interleukin (IL)-6, and serum amyloid A (SAA)] as potential determinants of future vascular events among otherwise healthy American women.
Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-KB activation in endothelial cells.
Stepkowski and Bennett described a number of results in a model of allogenic cardiac transplant in which mice were treated with Isis' antisense oligonucleotide to inhibit the expression of intercellular adhesion molecule 1 (ICAM-1).