intercalated disc


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in·ter·ca·la·ted disc

a specialized intercellular attachment of cardiac muscle cells comprising gap junctions, fascia adherens, and occasionally desmosomes.

in·ter·ca·la·ted disc

(in-tĕr'kă-lā-tĕd disk)
A histologic feature of cardiac muscle, occurring at the junction of two myocardial cells; site of intercellular passage of ions and electrical impulses.
References in periodicals archive ?
Normal distribution of atrionatriuretic factor (ANF) granules, an intact intercalated disc with clear identification of fully formed fascia adherence and desmosomes with a reconstruction of gap junction (nexus) were also noticed.
The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions.
Cardiac intercalated discs (IDs) incorporate numerous molecular complexes that, besides the transmission of electrical and biochemical signals serve as a linkage between cytoskeletons of adjacent cardiomyocytes to provide structural support of always mechanically stressed myocardial tissue.
Intercalated discs, numerous in the rat atrium of the sham-operated group, intersected the myocardial cells from one intercellular space to the next (Fig.
The nuclear matrix was mildly cavitative and nucleoli were visible with normal structure of intercalated disc, showing similar images to that of Res group.
The results from electron micrograph in normal and Res groups apparently showed the best image of myocardium that the cells arranged in neat rows, the gap was clear with a small amount of collagen fibers, sarcomere was clear; structure of intercalated disc and mitochondrial were normal.
Targeted deletion of mXin[alpha] gene, encoding an intercalated disc protein, leads to cardiac hypertrophy (Abstract).
Ablation of mXin[alpha] gene, encoding an intercalated discs protein (1), results in cardiac hypertrophy and cardiomyopathy with a reduction in connexin 43 expression (2).
The intercalated discs and the lateral borders were visualised by antibodies against cadherin and type IV collagen (for details see Bruel et al., 2007).
The reason for this is, that it is difficult to identify the intercalated discs and, also at times, to identify the lateral borders of the myocytes.
2) are tightly packed with obliquely striated myofibers and contact each other by small desmosomes and intercalated discs (Fig.
Microscope Digital Both n= 30 (32.3%) n= 34 (36.5%) n= 29 (31.2%) Cardiac muscle 22 (73.3%) 26 (76.5%) 27 (76.5%) Intercalated discs 11 (36.7%) 7 (20.6%) 6 (20.7%) Endomysium 17 (56.7%) 19 (58.8%) 26 (89.7%) Muscle fibers 17 (56.7%) 20 (58.8%) 24 (82.8%) Smooth muscle 22 (73.3%) 27 (79.4%) 28 (96.6%) Muscle fibers 19 (63.3%) 24 (70.6%) 25 (86.2%) Nucleus 17 (56.7%) 20 (58.8%) 23 (79.3%) Endomysium 12 (40.0%) 14 (41.2%) 23 (79.3%) Skeletal Muscle 27 (90.0%) 26 (79.5%) 22 (75.9%) Muscle fibers 25 (83.3%) 23 (67.7%) 20 (68.9%) Endomysium 28 (93.3%) 22 (64.7%) 24 (82.8%) Perimysium 29 (96.7%) 21 (61.8%) 23 (79.3%)