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To enable the use of intention-to-treat analysis, former drinkers (15%) and a small number of participants with unknown drinking status (2%) were treated as drinkers whose alcohol consumption level was unknown.
However, in the intention-to-treat analysis, the results were similar.
The CABANA steering committee anticipated a high crossover rate, but still set the intention-to-treat analysis as primary because "per protocol introduces many biases and can't be relied on for a study of this magnitude," Dr.
In the intention-to-treat analysis, the median change in pain from baseline to IUD insertion was 61 mm for women who used the lidocaine gel.
Selection criteria included a study population of at least 3000 patients and use of intention-to-treat analysis. Only 3 of the trials were double-blinded, and 2 were open-label.
In the intention-to-treat analysis, the primary outcome measure - health-related quality of life as assessed on the physical component summary score of the RAND SF-36 at 14 weeks--did not differ significantly among the three study groups.
In that trial's intention-to-treat analysis, the use of a selective [alpha.sub.2]-adrenergic receptor agonist (dexmedetomidine) resulted in better outcomes for delirious ICU patients who were on mechanical ventilation, compared with the use of a benzodiazepine (lorazepam).
After adjusting for baseline anti-fibrotic use in an intention-to-treat analysis, the researchers found that the rate of change in forced vital capacity over 48 weeks was −0.05 L (95 percent confidence interval, −0.15 to 0.05) in the surgery group and −0.13 L (95 percent confidence interval, −0.23 to −0.02) in the non-surgery group (P = 0.28).
In the meantime, the intention-to-treat analysis revealed that exenatide was noninferior to placebo with respect to safety (P less than .001) but was not superior to placebo with respect to safety (P = .06).
In an intention-to-treat analysis, the pregnancy rate was 61.2% with letrozole (Femara) versus 43% with clomiphene (P = .022).
In the intention-to-treat analysis, the rate of treatment success was 75% in patients randomly assigned to bracing, compared with 42% in those randomly assigned to observation only.
Using intention-to-treat analysis, the researchers found no difference in the recurrence rate of pyelonephritis between the groups.