intention-to-treat analysis


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intention-to-treat analysis

method of analyzing results of a randomized controlled trial that includes in the analysis all those cases that should have received a treatment regimen but for whatever reason did not. All cases allocated to each arm of the trial are analyzed together as representing that treatment arm, regardless of whether they received or completed the prescribed regimen.

intention-to-treat an·al·y·sis

(in-ten'shŭn-trēt ă-nal'i-sis)
Method of assessing results of a randomized controlled trial that includes in the analysis all the cases that should have received a treatment regimen but for some reason did not. All cases allocated to each arm of the trial are analyzed together as representing that treatment arm, regardless of whether they received or completed the prescribed regimen.
References in periodicals archive ?
To enable the use of intention-to-treat analysis, former drinkers (15%) and a small number of participants with unknown drinking status (2%) were treated as drinkers whose alcohol consumption level was unknown.
However, in the intention-to-treat analysis, the results were similar.
The CABANA steering committee anticipated a high crossover rate, but still set the intention-to-treat analysis as primary because "per protocol introduces many biases and can't be relied on for a study of this magnitude," Dr.
In the intention-to-treat analysis, the median change in pain from baseline to IUD insertion was 61 mm for women who used the lidocaine gel.
Selection criteria included a study population of at least 3000 patients and use of intention-to-treat analysis. Only 3 of the trials were double-blinded, and 2 were open-label.
In the intention-to-treat analysis, the primary outcome measure - health-related quality of life as assessed on the physical component summary score of the RAND SF-36 at 14 weeks--did not differ significantly among the three study groups.
In that trial's intention-to-treat analysis, the use of a selective [alpha.sub.2]-adrenergic receptor agonist (dexmedetomidine) resulted in better outcomes for delirious ICU patients who were on mechanical ventilation, compared with the use of a benzodiazepine (lorazepam).
After adjusting for baseline anti-fibrotic use in an intention-to-treat analysis, the researchers found that the rate of change in forced vital capacity over 48 weeks was −0.05 L (95 percent confidence interval, −0.15 to 0.05) in the surgery group and −0.13 L (95 percent confidence interval, −0.23 to −0.02) in the non-surgery group (P = 0.28).
In the meantime, the intention-to-treat analysis revealed that exenatide was noninferior to placebo with respect to safety (P less than .001) but was not superior to placebo with respect to safety (P = .06).
In an intention-to-treat analysis, the pregnancy rate was 61.2% with letrozole (Femara) versus 43% with clomiphene (P = .022).
In the intention-to-treat analysis, the rate of treatment success was 75% in patients randomly assigned to bracing, compared with 42% in those randomly assigned to observation only.
Using intention-to-treat analysis, the researchers found no difference in the recurrence rate of pyelonephritis between the groups.