intention to treat analysis


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intention to treat analysis

An analysis in which all trial participants are analysed according to the intervention to which they were allocated, whether they received that therapy or not. Such analyses are favoured in assessing effectiveness, as they mirror non-compliance and treatment changes likely to occur when the intervention is used in practice, and because of the risk of attrition bias when participants are excluded from the analysis.

intention to treat analysis

, intent to treat analysis
A clinical trial in which results from all randomized patients are included whether or not they actively participated in the complete study.
References in periodicals archive ?
Of the 394 individuals assessed for eligibility, 179 participants were enrolled and had a least some study drug, and were accordingly used in the intention to treat analysis.
The intention to treat analysis covered all randomised patients who received treatment (50 per group), while patients who discontinued or did not have a repeat biopsy were treated as non-responders.
The non-inferiority of the fixed-dose regimen was shown in the per protocol analysis and a post hoc modified intention to treat analysis, but not in the prespecified modified intention to treat analysis, where 83.
In the intention to treat analysis, there were 39,601 pregnancies and 138 pregnancy-related deaths in the vitamin A supplementation group (348 deaths per 100,000 pregnancies) compared with 39,234 pregnancies and 148 pregnancy-related deaths in the placebo group (377 per 100,000 pregnancies), (adjusted odds ratio 0.
In an intention to treat analysis, the rate of relapse flares during the first year of follow-up was virtually identical in the two treatment arms: a rate of 40.
This chapter is very informative, covering important concepts including intention to treat analysis, subgroup analysis, interactions between subgroups and ethical issues related to research in critical care.
Intention to treat analysis in clinical trials when there are missing data.
Results: In the intention to treat analysis of the entire sample, no group differences were observed in increments in BMC or bone dimensions during or after supplementation.
Intention to treat analysis is related to methodological quality.
Table 2 presents cumulative gain (area-under-the-curve) comparisons for the intention to treat analysis for the Composite Health Index (i.
Per protocol analysis and intention to treat analysis
According to the company, the proportion of patients meeting the POISE primary endpoint were 10 percent in the placebo group, 47 percent in the 10mg OCA group and 46 percent in the 5-10mg OCA group in an intention to treat analysis.