intention to treat

intention to treat

In clinical trials, the principle that holds that the effect of a treatment regimen can be best assessed by evaluating the basis of the intention to treat a subject (i.e., the planned treatment regimen), rather than the actual treatment given. Thus, subjects allocated to a treatment group should be followed, assessed and analysed as members of the treatment group irrespective of their compliance with the planned course of treatment. The principle of intention to treat is meant to prevent bias caused by loss of trial participants, which may reflect non-adherence to the protocol and disrupt baseline equivalence established by random assignment.
References in periodicals archive ?
9 per 1,000 person-years in controls, for a highly significant 35 percent relative risk reduction in a fully adjusted multivariate intention to treat analysis.
The Mexican authorities stated their intention to treat the arrangement as precautionary.
The Colombian authorities stated their intention to treat the new arrangement as precautionary and do not intend to draw on it.
The primary efficacy analysis was conducted on an intention to treat basis, testing the dose dependent effects of once daily OCA (10mg, 20mg and 40mg) compared with placebo.
The hospital said that it carried out a full investigation into the incident and apologised to the family, adding that it is "always our intention to treat all deceased patients with the highest levels of dignity and respect".
This is the intention to treat principle used in clinical trials which reduces the potential for bias associated with exposed subjects who have adverse outcomes and subsequently withdraw from treatment.
But Hodgson has confirmed his intention to treat the 20-year-old with kid gloves and has already confirmed Wilshere will not start in the new 50,000-capacity Friends Arena.
The ITT (intention to treat) analysis detects 13 failures in the control group (eight lost to follow up + five thrombotic events) of 105 subjects (12.4%) vs.
The non-inferiority of the fixed-dose regimen was shown in the per protocol analysis and a post hoc modified intention to treat analysis, but not in the prespecified modified intention to treat analysis, where 83.3% (570/684) of patients had a favourable outcome (negative culture result at 18 months) in the fixed-dose group compared with 84.8% (563/664) in the separate drugs group (risk difference -1.5%, 90% CI: 4.7 - 1.8%).
In the intention to treat analysis, there were 39,601 pregnancies and 138 pregnancy-related deaths in the vitamin A supplementation group (348 deaths per 100,000 pregnancies) compared with 39,234 pregnancies and 148 pregnancy-related deaths in the placebo group (377 per 100,000 pregnancies), (adjusted odds ratio 0.92, p=0.51).
"There is no intention to treat residents of the west Bank who are