intention to treat

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intention to treat

In clinical trials, the principle that holds that the effect of a treatment regimen can be best assessed by evaluating the basis of the intention to treat a subject (i.e., the planned treatment regimen), rather than the actual treatment given. Thus, subjects allocated to a treatment group should be followed, assessed and analysed as members of the treatment group irrespective of their compliance with the planned course of treatment. The principle of intention to treat is meant to prevent bias caused by loss of trial participants, which may reflect non-adherence to the protocol and disrupt baseline equivalence established by random assignment.
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Tecentriq in combination with chemotherapy met the primary endpoint of overall survival as compared with chemotherapy alone in the intent to treat analysis.
Tecentriq receives approval for additional indication of extensive-stage SCLC
LOI was defined as a SLEDAI increase >=4 points or a new BILAG A or B score and physician intent to treat with rescue medication.
Xencor Releases Topline Results from Phase 2 Study of XmAb5871 in Systemic Lupus Erythematosus
According to the company, the study failed to indicate a statistically significant difference from placebo in the intent to treat population.
Amicus Therapeutics fails to meet primary endpoints and secondary endpoints in clinical study of SD-101
We added a time-dependent interaction effect with the radiotherapy indicator to assess the consistency of our main findings (overall, low and high risk intent to treat results) over time.
Prostate cancer-specific survival differences in patients treated by radical prostatectomy versus curative radiotherapy
The results on the intent to treat (ITT) population demonstrated that the change in average daily neuropathy intensity scores in the NP-1 group achieved a statistically significant reduction in CPN intensity versus placebo, which was the trial's primary endpoint.
-EpiCept unveils positive phase IIb data with NP-1
Improvements in global function were also evaluated as a coprimary study endpoint and were not found to achieve statistical significance, as evaluated by changes from baseline in the Clinician's Interview-Based Impression of Change Plus Caregiver Input scores (4.23 vs 4.29; intent to treat, P = .1789).
United States : FDA Approves High-Dose Donepezil for Advanced Alzheimers Disease
Thoratec said forty-six percent of the HeartMate II patients successfully achieved the primary composite endpoint of survival at two years while remaining free from disabling stroke or the need for reoperation to replace or repair the pump versus 11% of the SVE patient cohort, on an intent to treat basis.
Thoratec reports new trial for HeartMate II LVAS demonstrates survival rate superior to HeartMate XVE device
Statistical considerations in the intent to treat principle.
FRISBEE: does the study fly in the face of evidence-based medicine? Carefully examine the validity of clinical trials before translating the results into your practice
Moreover, the phrase "symptoms for which you received medical care" connotes an intent to treat or uncover the particular ailment that causes that symptom--even absent a timely diagnosis--rather than some nebulous or unspecified medical problem.
Before the fact: a ruling says carriers cannot "read back" a pre-existing condition that went undiagnosed in the look-back period
["Intent to treat" analysis compares the total percent of volunteers who meet the study-defined success criterion alter being assigned to take one drug vs.
New fixed-dose once-a-day starting regimens: interview with Cal Cohen, M.D
Blood samples that were taken every 2 weeks showed that the supplement significantly slowed the rate of PSA increase in both an intent to treat analysis of 46 patients who had at least two serum PSA readings per treatment and an analysis of 42 patients who had five PSA readings per treatment as called for in the protocol.
Use of soy-based supplement slows increase in PSA levels; post-prostate cancer trial
Despite the assurances he gave to Russ Feingold during confirmation hearings, saying that he "had no intent to treat this group [gays and lesbians] differently than any other," Ashcroft forbade a gay-pride awards ceremony that had been scheduled for June 18 and that had been an annual observance for the past six years.
Gay shame month. (Devil in the Details)

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