intention to treat

(redirected from intent to treat)

intention to treat

In clinical trials, the principle that holds that the effect of a treatment regimen can be best assessed by evaluating the basis of the intention to treat a subject (i.e., the planned treatment regimen), rather than the actual treatment given. Thus, subjects allocated to a treatment group should be followed, assessed and analysed as members of the treatment group irrespective of their compliance with the planned course of treatment. The principle of intention to treat is meant to prevent bias caused by loss of trial participants, which may reflect non-adherence to the protocol and disrupt baseline equivalence established by random assignment.
Mentioned in ?
References in periodicals archive ?
Both the Intent to Treat (ITT) and Per Protocol (PP) patients treated with SQ109-containing regimens showed statistically significant improvement in clearance of lung bacteria.
Infectex's Pulmonary Tuberculosis drug achieves Positive Phase 2b-3 Clinical Trial Results
We added a time-dependent interaction effect with the radiotherapy indicator to assess the consistency of our main findings (overall, low and high risk intent to treat results) over time.
Prostate cancer-specific survival differences in patients treated by radical prostatectomy versus curative radiotherapy
Thoratec said forty-six percent of the HeartMate II patients successfully achieved the primary composite endpoint of survival at two years while remaining free from disabling stroke or the need for reoperation to replace or repair the pump versus 11% of the SVE patient cohort, on an intent to treat basis.
Thoratec reports new trial for HeartMate II LVAS demonstrates survival rate superior to HeartMate XVE device
Statistical considerations in the intent to treat principle.
FRISBEE: does the study fly in the face of evidence-based medicine? Carefully examine the validity of clinical trials before translating the results into your practice
Moreover, the phrase "symptoms for which you received medical care" connotes an intent to treat or uncover the particular ailment that causes that symptom--even absent a timely diagnosis--rather than some nebulous or unspecified medical problem.
Before the fact: a ruling says carriers cannot "read back" a pre-existing condition that went undiagnosed in the look-back period
Blood samples that were taken every 2 weeks showed that the supplement significantly slowed the rate of PSA increase in both an intent to treat analysis of 46 patients who had at least two serum PSA readings per treatment and an analysis of 42 patients who had five PSA readings per treatment as called for in the protocol.
Use of soy-based supplement slows increase in PSA levels; post-prostate cancer trial
In another type of analysis, known as intent to treat, researchers include the consequences of a drug's side effects and dosing schedule and count all the patients in a study, whether they take the medication or not.
Out of the laboratory and into the bathroom cabinet: designing and implementing clinical trials. (Clinical Trials)
The Seventh Circuit disagreed since the taxpayers had not clearly indicated on their 1994 return their intent to treat the rentals as a single activity.
Self-rental regulation upheld again
An economic benefit is not consideration for the performance of services, unless the organization providing the benefit clearly indicates its intent to treat the benefit as compensation when it is paid.
IRS issues intermediate-sanctions regulations
The legislative history of section 902 evinces congressional intent to treat foreign subsidiaries and branches similarly.
Proposed section 902 regulations
The pooled pre-defined intent to treat (ITT) population excluded study patients without histological evidence of active disease at baseline or with major eligibility or Good Clinical Practice violations.
Santarus unveils positive results from Phase III trials of budesonide MMX
Although the court in Compaq "shammed" the ADR transactions (because Compaq eliminated virtually all market risk), the IES Industries court actually noted that the carefully orchestrated elimination of market risk was evidence of IES Industries' intent to treat the ADR transactions as moneymaking.
Business-purpose and economic-substance tests. (Corporations & Shareholders)

Medical browser ?
Full browser ?