integrins


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in·te·grins

(in-te'grinz),
A family of cell membrane glycoproteins that are heterodimers composed of α- and β-chain subunits. They serve as extracellular matrix glycoprotein receptors involved in cell adhesion, for example, the mediation of adhesion of neutrophils to endothelial cells.
[L. integer, whole, intact, fr. in- + tango, to touch + -in]

integrins

A familty of linked polypeptide chains, alpha and beta, that mediate adhesions and other interactions between cells and the extracellular matrix and between cells and other cells. Integrins are expressed on endothelial cells, leukocytes, other cells and platelets, and act as receptors for fibrinogen, fibronectin, thrombospondin, von Willebrand factor, and vitronectin. See also DISINTEGRINS.
References in periodicals archive ?
However, raising the calcium concentration to 1.0mM resulted in stratification as well as differentiation and stratification is generally held to involve the reduction in the affinity of the extracellular matrix receptors, the integrin for their ligands, which include FN.10 in the present study it was first investigated whether the cells exited the cell cycle in these different calcium concentrations by staining the cultures with Ki67, an antibody specific for cells in cycle.
Furthermore, the protective effects of collagen I and fibronectin were mediated through the [alpha]2[beta]1 and [alpha]5[beta]1 integrins, respectively.
Wei, "Protease crosstalk with integrins: the urokinase receptor paradigm," Thrombosis and Haemostasis, vol.
Lee, "Modulation of signaling between TM4SF5 and integrins in tumor microenvironment," Frontiers in Bioscience, vol.
Santoro, "Integrins and the kidney: biology and pathobiology," Current Opinion in Nephrology and Hypertension, vol.
Of these, the integrin-collagen complex is a pharmacologically tractable target; various integrin signaling inhibitors include ITGA5 inhibitors (JSM 6427, PF-04605412, Volociximab, and Vitaxin), ITGB1 inhibitors (Volociximab, JSM 6427, R411, Vitaxin, and PF-04605412), and an ITGAV inhibitor (L000845704) (Figure 2(e)).
Its portfolio of integrin antagonists has potential utility in a broad range of fibrotic diseases.
Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin.
Furthermore, when they artificially activated integrin in mice with aged muscles, their regenerative abilities were restored to youthful levels.
Cells adhere to this matrix via cell surface proteins called integrins. Talin is the main linker protein coupling integrins to the cell's force generating machinery, engaging integrin at one end and coupling it to the cytoskeleton.
When T cells recognize a specific target, such as a cell infected with a virus, they activate sticky proteins known as integrins that allow them to attach to their target and, in the case of a virally infected cell, kill it.

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