ITGB1

(redirected from integrin beta-1)

ITGB1

A gene on chromosome 10p11.2 that encodes an integrin beta chain protein, which forms part of receptors (with different alpha chains) for collagen, fibronectin, fibrinogen, laminin, VCAM1, cytotactin, osteopontin, vitronectin, epiligrin, thrombospondin and CSPG4. It is involved in embryogenesis, haemostasis, tissue repair, immune response and metastatic spread of malignant cells.
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References in periodicals archive ?
CD29, Integrin beta-1, is a protein encoded by ITGB1 gene in humans (Goodfellow et al., 1989).
[sup][24] The integrin alpha-11 subunit binds the integrin beta-1 subunit to form a heterodimer, and a[sub]11 [sz][sub]1 integrin is one of the four receptors for interstitial collagen to modulate the growth of NSCLC cells.