ITGA1

(redirected from integrin alpha-1)

ITGA1

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. The alpha-1 beta-1 heterodimer forms a cell surface receptor for collagen and laminin, is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.
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Antiantibodies antibodies made against specific to integrin alpha-1 and isoform-1 of multimerin-1 (Abcam, Cambridge, MA, USA) were used at 1:1000 and 1:2000 dilution, respectively.