ITGA2(redirected from integrin alpha 2)
Also found in: Wikipedia.
ITGA2A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha-2 beta-1 heterodimers serve as receptors for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, and is responsible for adhesion of platelets and other cells to the extracellular matrix, modulation of collagen and collagenase gene expression and organisation of newly synthesised extracellular matrix.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.