integrin


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integrin

(ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

integrin

a receptor PROTEIN allowing cells to bind to and respond to the EXTRACELLULAR MATRIX. Integrins are members of a large family of cell adhesion receptors involved in cell-extracellular matrix and cell-cell interactions. see ANOIKIS.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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The collaboration concentrates on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.
Morphic Therapeutic signs research and development collaboration with Janssen Biotech
Additionally, Morphic Therapeutic' scientific founder Tim Springer has developed a unique platform for designing integrin oral inhibitors to block TGF-?
AbbVie & Morphic partnership to develop oral integrin drugs targeting fibrotic diseases
CRT, a molecular chaperone(5), binds to integrin subunits and promotes cell adhesion (Reference document 2).
Eisai: Potent New Mechanism of Action for Treatment of Inflammatory Bowel Disease
[13.] Hughes AL (2001) Evolution of the integrin alpha and beta protein families.
Extracellular Matrix Components in Bivalvia: Shell and ECM Components in Developmental and Adult Tissues
The expression and localization of [alpha]4, [beta]1, [alpha]v, and [beta]6 integrin subunits were investigated using flow cytometry and immunofluorescence staining.
Calcium Mobilization and Inhibition of Akt Reduced the Binding of PEO-1 Cells to Fibronectin/[Ca.sup.2+] Mobilizasyonu ve Akt Inhibisyonu ile PEO-1 Hucrelerinin Fibronektine Baglanmasinda Azalma
The aim of this study was to determine the gene and protein expression levels and localization of the focal adhesion proteins vinculin and integrin [beta]5 in the rat uterine epithelial cells during implantation in vivo.
Focal Adhesion Proteins, Vinculin and Integrin [beta]5, During Early Pregnancy in Rat Uterine Epithelial Cells: Anastrozole Favors their Normal Distribution/Proteinas de Adhesion Focales, Vinculina e Integrina [beta]5, Durante el Embarazo Temprano en Celulas Epiteliales Uterinas de Rata: Anastrozol Favorece Su Distribucion Normal
Three leukocyte adhesion deficiency (LAD) disorders have been well recognized, caused by genetic defects in Beta 2 integrin family consist of LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), Complement receptor 4 (CD11c/CD18), and (CD11d/CD18).1
Leukocyte adhesion defect: An uncommon immunodeficiency
Cell Culture and Analysis of Integrin [[alpha].sub.v][[beta].sub.3] Expression.
Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging
Expressions of cytokeratin, vimentin, integrin avfi3, and leukemia inhibitory factor (LIF) proteins were performed by incubating slides of rat uteri with rabbit polyclonal antibodies against cytokeratin, vimentin, integrin avfi3, and LIF overnight at 4[degrees]C.
Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model
Immunofluorescence staining was performed as previously described [25] using primary antibodies against integrin-[alpha]2 (mouse, Santa Cruz Biotechnology, sc-74466) and collagen type 1 (rabbit, Abcam, ab34710) as set 1 as well as integrin [alpha]6 (rabbit, Invitrogen, 710201) and laminin-[beta]3 (mouse, Santa Cruz Biotechnology, sc-33178) as set 2 along with Alexa Fluor[R] dye-conjugated anti-rabbit and anti-mouse (Thermo Fisher Scientific) secondary antibodies to detect the expression of the integrin receptors on the surface of the cells in response to the polymer matrices.
Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models
Bendeck, "Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells," Cell Adhesion & Migration, vol.
OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics

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