integrase inhibitor


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integrase inhibitor

Any agent that prevents the human immunodeficiency virus from inserting its viral DNA into host cell chromosomes.
See also: inhibitor
References in periodicals archive ?
Raltegravir: the first HIV type 1 integrase inhibitor.
An important finding is that people starting treatment with the integrase inhibitor Isentress ran a much lower risk of drug-drug interactions than did people starting treatment with a PI (such as Reyataz or Prezista) or an NNRTI (such as Sustiva or Viramune).
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137).
Integrase inhibitors are an investigational class of antiretrovirals that interfere with HIV replication by blocking the ability of the virus to integrate into the genetic material of human cells.
A key growth driver of the HIV therapy market will be the increasing uptake of new, premium-priced agents, including integrase inhibitors and integrase inhibitor-based STRs.
The US Food and Drug Administration has approved Isentress HD, a new 1200 mg once-daily dose of US-based pharmaceutical company Merck's (NYSE: MRK) integrase inhibitor, Isentress (raltegravir), to be administered orally as two 600 mg film-coated tablets with or without food, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults, and pediatric patients weighing at least 40 kg, who are treatment-naive or whose virus has been suppressed on an initial regimen of Isentress 400 mg given twice daily, the company said.
This investigational single tablet regimen brings together the potency of an integrase inhibitor, bictegravir, with the demonstrated efficacy and safety profile of the FTC/TAF backbone, said Norbert Bischofberger, PhD, Executive Vice President, Research and Development and Chief Scientific Officer, Gilead Sciences.
The only drug in the integrase inhibitor class approved for the treatment of HIV-1 infection as part of combination antiretroviral therapy raltegravir also appears to be better tolerated than efavirenz and has a more favorable metabolic profile, according to 4 years of follow-up data presented by Dr.
The study is the first of a gel with an integrase inhibitor, one of the latest additions to the arsenal of drugs for the treatment of HIV but just one of the many compounds or drug combinations that researchers are hoping will be a stronghold for HIV prevention.
The Imperial and Harvard scientists said that having the integrase structure means researchers can begin fully to understand how integrase inhibitor drugs work, how they might be improved, and how to stop HIV developing resistance to them.
Isentress, the only integrase inhibitor approved by the Food and Drug Administration, may also be taken by people who have or have not used antiretrovirals before.
Currently their use is reserved for heavily treatment-experienced and drug-resistant patients for whom there are few additional potent agents to couple with the integrase inhibitor.