integrase inhibitor


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integrase inhibitor

Any agent that prevents the human immunodeficiency virus from inserting its viral DNA into host cell chromosomes.
See also: inhibitor
References in periodicals archive ?
Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis.
ISENTRESSA (raltegravir), from MSD, was as Effective as Efavirenz at Suppressing HIV Viral Load and Increasing CD4 Cell Counts in Treatment-NaE[macron]ve Patients up to 144 Weeks When Used in Combination Therapy CAPE TOWN, South Africa--(BUSINESS WIRE)-- Not For Distribution To South African Journalists ISENTRESS A (raltegravir), an integrase inhibitor from Merck Sharpe & Dohme (MSD) was as effective as efavirenz at maintaining viral load suppression to undetectable levels (less than 50 copies/mL) and at improving CD4 counts in previously untreated (treatment-naE[macron]ve) patients through 144 weeks in a Phase II study still underway.
Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 857, 15-24.
The drug received approval to treat HIV-1 infection in adults, who are virologically suppressed on a stable antiretroviral regimen for around six months with no history of virological failure and no experienced or suspected resistance to any non-nucleoside reverse transcriptase inhibitor or integrase inhibitor. The approval enables the provision of treatment for around 810,000 PLHIV patients in Europe.
ViiV Healthcare will seek to prove that Gilead Sciences' triple combination HIV drug containing the HIV integrase inhibitor bictegravir infringes ViiV Healthcare's patent covering ViiV Healthcare's dolutegravir and many other compounds that include dolutegravir's unique chemical scaffold.
Cabotegravir is an HIV integrase inhibitor, rilpivirine a nonnucleoside reverse transcriptase inhibitor.
Almost everyone who started therapy after 1999 had a fully active protease inhibitor and a fully active integrase inhibitor available.
The product combines the novel HIV integrase inhibitor elvitegravir with a novel "boosting" agent, cobicistat, and Gilead's dual nucleoside/nucleotide reverse transcriptase inhibitor regimen Truvada (emtricitabine/tenofovir).
Since February we have received positive Phase III data on three assets--our HIV integrase inhibitor, Albigutide for diabetes and our B-Raf inhibitor for treatment of melanoma.
The study is the first of a gel with an integrase inhibitor, one of the latest additions to the arsenal of drugs for the treatment of HIV but just one of the many compounds or drug combinations that researchers are hoping will be a stronghold for HIV prevention.
The Imperial and Harvard scientists said that having the integrase structure means researchers can begin fully to understand how integrase inhibitor drugs work, how they might be improved, and how to stop HIV developing resistance to them.
and Shionogi Limited as shareholders, today announced that the European Commission has granted Marketing Authorisation for Dovato (dolutegravir/lamivudine) for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine.