insulinoma

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insulinoma

 [in″su-lin-o´mah]
a tumor of the beta cells of the islets of Langerhans; although usually benign, it is one of the chief causes of hypoglycemia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

in·su·li·no·ma

(in'sŭ-li-nō'mă),
An islet cell adenoma that secretes insulin.
Farlex Partner Medical Dictionary © Farlex 2012

insulinoma

A well-differentiated pancreatic endocrine neoplasm associated with Whipple's triad:
(1) Symptoms and signs of hypoglycaemia;
(2) Concomitant plasma glucose level of 45 mg/dL or less; and
(3) Symptoms reverse with the administration of glucose. Amyloid is often found in insulinomas.

Prognosis
Insulinomas, especially if small, have an excellent prognosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

insulinoma

Insuloma Oncology A pancreatic islet cell tumor, which is characterized by overproduction of insulin, resulting in hypoglycemia of sufficient severity to trigger a coma; insulinomas are typical of MEN I. See MEN I.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

in·su·li·no·ma

(in'sŭ-li-nō'mă)
An islet cell adenoma that secretes insulin.
Synonym(s): insuloma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

insulinoma

A rare tumour of the INSULIN -producing cells of the PANCREAS. Insulinomas can produce large quantities of insulin and lead to the dangerous condition of HYPOGLYCAEMIA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Insulinoma

Tumor that arises from the insulin-producing cells in the pancreas.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
In this case report we wanted to remind and emphasize the existence of two insulinoma cases who applied to the neurology and psychiatry clinics before diagnosis and who used long term un necessary antiepileptic drugs due to misdiagnosis of epilepsy or psychiatric disorders.
Recurrence of insulinoma was diagnosed with laboratory tests, which revealed plasma glucose, insulin, and C-peptide levels of 38 mg/dL, 23.2 mcU/mL, and 2.71 ng/mL, respectively.
Unexpectedly, this gene defect was present in both the family members with diabetes and those with insulinomas, and was also identified in a second, unrelated family with the same unusual dual picture.
Data was collected on the clinical picture, laboratory findings, imaging, pathology, treatment, and follow-up of insulinomas. The symptoms were classified as neuroglycopenic and autonomic.
Maiter, "Successful endoscopic ultrasound-guided ethanol ablation of a sporadic insulinoma," Acta Gastroenterologica Belgica, vol.
Insulinomas are rare pancreatic neuroendocrine tumors, but they should always be considered in the differential diagnosis of any patient presenting with frequent hypoglycemic symptoms.
Insulinoma is a very rare tumor in children and adolescents.
Solomonov et al., "Pasireotide for malignant insulinoma," Hormones, vol.
Using MIN6N8 cells, which are SV40 transformed insulinoma cells derived from NDO mice, Kim et al., extensively studied the effects of chronic hyperglycemia in the tissue culture: when MIN6N8 cells were cultured in different concentrations of glucose for varying time periods: The high glucose (33.3 mmol/l) induced marked genomic DNA fragmentation in a time- and dose-dependent manner and caused a significant increase of TUNEL-positive cells compared to the low glucose (5.5 mmol/l) cultured cells, concomitant cleavage of poly (adenosine diphosphate [ADP]-ribose) polymerase (RARP) similar to caspase-3 cleavage (Figure 7A) [80].
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature.