insulinoma


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Related to insulinoma: hypoglycemia

insulinoma

 [in″su-lin-o´mah]
a tumor of the beta cells of the islets of Langerhans; although usually benign, it is one of the chief causes of hypoglycemia.

in·su·li·no·ma

(in'sŭ-li-nō'mă),
An islet cell adenoma that secretes insulin.

insulinoma

/in·su·li·no·ma/ (in″sdbobr-lin-o´mah) an islet cell tumor of the beta cells, usually benign, that secretes insulin and is one of the chief causes of hypoglycemia.

insulinoma

[in′səlinō′mə] pl. insulinomas, insulinomata
Etymology: L, insula + Gk, oma, tumor
a tumor, usually benign, of the insulin-secreting cells of the islets of Langerhans. Surgical resection of the tumor may be possible, thus limiting the development of hypoglycemia. Also called insuloma, islet cell adenoma. Compare islet cell tumor.
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Insulinoma

insulinoma

A well-differentiated pancreatic endocrine neoplasm associated with Whipple's triad:
(1) Symptoms and signs of hypoglycaemia;
(2) Concomitant plasma glucose level of 45 mg/dL or less; and
(3) Symptoms reverse with the administration of glucose. Amyloid is often found in insulinomas.

Prognosis
Insulinomas, especially if small, have an excellent prognosis.

insulinoma

Insuloma Oncology A pancreatic islet cell tumor, which is characterized by overproduction of insulin, resulting in hypoglycemia of sufficient severity to trigger a coma; insulinomas are typical of MEN I. See MEN I.

in·su·li·no·ma

(in'sŭ-li-nō'mă)
An islet cell adenoma that secretes insulin.
Synonym(s): insuloma.

insulinoma

A rare tumour of the INSULIN -producing cells of the PANCREAS. Insulinomas can produce large quantities of insulin and lead to the dangerous condition of HYPOGLYCAEMIA.

Insulinoma

Tumor that arises from the insulin-producing cells in the pancreas.

insulinoma

a tumor of the beta cells of the islets of Langerhans; although usually benign, it is one of the chief causes of hypoglycemia.
References in periodicals archive ?
Aproximadamente 10% son multiples, 10% son malignos y 16% estan asociados a sindrome MEN-1, por otro lado solo el 21% de los paciente con MEN-1 desarrolla insulinoma durante su vida.
Control of glucose phosphorylation and glucose usage in clonal insulinoma cells.
The nodule was determined to be an insulinoma on histological analysis.
Transient alteration of cell fate using a nuclear and cytoplasmic extract of an insulinoma cell line.
Animal insulinoma cell lines, including NIT-1 cells of mouse origin, are often used as in vitro models to study the functions of pancreatic [beta] cells.
Insulinoma associated-2 autoantibodies (1A-2A) were initially discovered when researchers were screening proteins produced by insulinotna cells for their reactivity with sera from subjects with type I diabetes.
The sensitivity is reduced if there is a lack of SSTR2 expression, as is seen in poorly differentiated NETs and insulinomas.
Topics include: hypoadrenocorticism in dogs and other species, primary functioning adrenal tumors producing signs similar to hyperadrenocorticism including atypical syndromes in cats, diabetes mellitus in dogs and other species, insulinoma, hypothyroidism, hyposomatotropism, acromegaly, estrogen- and androgen-related disorders, and adrenal dysfunction and sex hormones.
Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.
2004); protective action of plant extract against oxidative stress induced by streptozotocin in male Wistar rats and in Rat insulinoma cell lines (RINm5F) and isolated islets (Latha et al.
Recent findings in MIN6 cells (mou se insulinoma cells) seem to support this idea.
Fato este que levou o animal ao procedimento cirurgico que e o tratamento de eleicao para o insulinoma (8).