insulinlike growth factor


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in·su·lin·like growth factor (IGF),

(formerly termed somatomedin C), the most important somatomedin for postnatal growth; it is produced in the liver, kidney, muscle, pituitary, the gastrointestinal tract, and chondrocytes. IGF-I is a basic protein (7600 MW) that circulates bound to six distinct IGF binding proteins (IGF-BPs), which increase the half-life of circulating IGF-I to 3-18 hours, as compared with the half-life of 20-30 minutes for unbound hormone. Local tissue generation of IGF-I/SM-C, particularly in bone, may play an important role in growth mediation through its paracrine effects.
Synonym(s): somatomedins

in·su·lin·like growth fac·tor

(IGF) (insŭ-lin grōth faktŏr)
Most important somatomedin for postnatal growth; produced in the liver, kidney, and elsewhere.
References in periodicals archive ?
However, the phosphorylated insulinlike growth factor binding pro-tein-1 (ph IGFBP-1) test (marketed outside the United States as the Actim Partus test) costs about one-fourth as much as the fetal fibronectin test.
A study of 384 aged Ashkenazi Jews shows that a decrease in insulinlike growth factor 1 (IGF-1) activity is associated with long life, Nit Barzilai and his colleagues report in the March 4 Proceedings of the National Academy of Sciences.
The insulin-like growth factor (IGF) is a complex system of peptide hormones (insulin-like growth factors of type 1 and 2, IGF-1 and IGF-2), cell surface receptors (insulin receptor, IR; insulin-like growth factor receptors of type 1 and 2, IGF-R1, IGF-R2) and circulating binding proteins (insulinlike growth factor binding proteins, IGF-BP 1-6).
We evaluated hepatic mRNA for insulinlike growth factor binding protein 1 (IGF BP1) from selected mice by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR).
Milk from rBST-treated cows may also contain slightly greater amounts of insulinlike growth factor I, which is active in humans.
Instead, growth hormone stimulates insulinlike growth factor (IGF-1 and IGF-2) production in the liver, which is responsible for cellular reproduction in all tissues.
Thierry Simonart of Brussels noted that the observations are "in line with biochemical and epidemiological data supporting the effects of milk and dairy products as enhancers of insulin/ insulinlike growth factor 1 signaling and acne aggravation" (Dermatology 2012;225:256-8).
"I don't think anyone has suggested that insulin causes cancer, but it is a growth-promoting hormone." The mechanism is likely to relate to insulin's binding of insulinlike growth factor receptors on tumors, said Dr.
Median concentrations of osteopontin, insulinlike growth factor (IGF)-II, leptin, and prolactin in preoperative serum samples were not significantly different between women with benign ovarian neoplasm and those with ovarian cancer, Dr.
Serum concentrations of insulinlike growth factor I (IGF-I), [5] which together with IGF binding protein 3 (IGFBP-3) and the acid labile subunit (ALS) forms the circulating IGF-I ternary complex, are clinically useful markers for the management of growth disorders and metabolic diseases (1-3) and for cancer development and progression (4-6).
Repopulation of the atrophied thymus in diabetic rats by insulinlike growth factor. Proc Natl Acad Sci USA.
Other recommended studies include a complete blood count; chemistry panel; free thyroxine (free T4) with thyroid-stimulating hormone (TSH); insulinlike growth factor 1 (IGF-1), C-reactive protein, urinalysis, and a celiac panel (IgG and IgA class of anti--tissue transglutaminase [anti-tTG]; antiendomysial antibodies, IgA class [EMA-IgA]; and quantitative IgA).