insulinlike growth factor


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in·su·lin·like growth factor (IGF),

(formerly termed somatomedin C), the most important somatomedin for postnatal growth; it is produced in the liver, kidney, muscle, pituitary, the gastrointestinal tract, and chondrocytes. IGF-I is a basic protein (7600 MW) that circulates bound to six distinct IGF binding proteins (IGF-BPs), which increase the half-life of circulating IGF-I to 3-18 hours, as compared with the half-life of 20-30 minutes for unbound hormone. Local tissue generation of IGF-I/SM-C, particularly in bone, may play an important role in growth mediation through its paracrine effects.
Synonym(s): somatomedins

in·su·lin·like growth fac·tor

(IGF) (insŭ-lin grōth faktŏr)
Most important somatomedin for postnatal growth; produced in the liver, kidney, and elsewhere.
References in periodicals archive ?
However, the phosphorylated insulinlike growth factor binding pro-tein-1 (ph IGFBP-1) test (marketed outside the United States as the Actim Partus test) costs about one-fourth as much as the fetal fibronectin test.
Thierry Simonart of Brussels noted that the observations are "in line with biochemical and epidemiological data supporting the effects of milk and dairy products as enhancers of insulin/ insulinlike growth factor 1 signaling and acne aggravation" (Dermatology 2012;225:256-8).
The mechanism is likely to relate to insulin's binding of insulinlike growth factor receptors on tumors, said Dr.
Median concentrations of osteopontin, insulinlike growth factor (IGF)-II, leptin, and prolactin in preoperative serum samples were not significantly different between women with benign ovarian neoplasm and those with ovarian cancer, Dr.
Other recommended studies include a complete blood count; chemistry panel; free thyroxine (free T4) with thyroid-stimulating hormone (TSH); insulinlike growth factor 1 (IGF-1), C-reactive protein, urinalysis, and a celiac panel (IgG and IgA class of anti--tissue transglutaminase [anti-tTG]; antiendomysial antibodies, IgA class [EMA-IgA]; and quantitative IgA).
The insulinlike growth factor I receptor may offer a much-needed therapeutic target for triple-negative breast cancer, which can be notoriously hard to treat.
Baseline serum levels of fasting insulin, estradiol, glucose, free and total insulinlike growth factor 1 (IGF-1), and IGF binding protein-3 were available for all subjects.
In the late 1990s, the GH-2000 Study Group, supported in part by grants from the international Olympic Committee and the European Union, conducted studies on the effects of GH administration on the insulinlike growth factor (IGF) axis and markers of bone and collagen turnover, with the hope that GH doping would reveal itself in patterns of test results among the large number of biomarkers influenced by GH, providing the basis for an indirect method of GH doping detection (10-13).
Glucose, insulin, insulinlike growth factor 1, lipopolysaccharide, proinflammatory cytokines, and sex hormones are external factors that affect the hippocampus.
One copy of a particular imprinted gene, which makes a protein called insulinlike growth factor 2 (IGF2), is normally turned off when inherited from an animal's mother.
Serum concentrations of insulinlike growth factor I (IGF-I), [5] which together with IGF binding protein 3 (IGFBP-3) and the acid labile subunit (ALS) forms the circulating IGF-I ternary complex, are clinically useful markers for the management of growth disorders and metabolic diseases (1-3) and for cancer development and progression (4-6).
Of the injured patients, 16% had subnormal peak cortisol responses and 18% had subnormal growth hormone responses; these findings were unrelated to age, body mass index, initial Glasgow Coma Score (GCS), or levels of insulinlike growth factor I.