IGFBP3

(redirected from insulin-like growth factor-binding protein 3)

IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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DENVER -- Open, but not laparoscopic, colectomy for colorectal cancer induces a sharp decrease in circulating levels of intact insulin-like growth factor-binding protein 3, a cell-growth regulatory protein with rumor-suppressive effects, Irena Kirman, Ph.D., reported at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons.
Kirman reported on 15 colon cancer patients who underwent open colectomy and 16 who had laparoscopic colectomy, Mean concentration of circulating intact insulin-like growth factor-binding protein 3 (IGFBP-3) was reduced by three-quarters on postoperative day 2, from a preoperative level of roughly 2,000 ng/mL, in the open surgery group.
DENVER -- Open, but not laparoscopic, colectomy for colorectal cancer induces a dramatic decrease in circulating levels of intact insulin-like growth factor-binding protein 3, a cell-growth regulatory protein with tumor-suppressive effects, Irena Kirman, Ph.D., reported at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons.

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