insulin-dependent diabetes mellitus type 19

insulin-dependent diabetes mellitus type 19

A multifactorial disorder of glucose homeostasis (OMIM:610155) characterised by susceptibility to ketoacidosis in the absence of insulin therapy.

Clinical findings
Polydipsia, polyphagia, polyuria due to hyperglycaemia-induced osmotic diuresis and secondary thirst. Long-term diabetic complications affect the eyes, kidneys, nerves and blood vessels.

Molecular pathology
Defects of IFIH1, which encodes an RNA helicase, cause IDDM19.
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