insulin tolerance test


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insulin tolerance test

a test of the body's ability to use insulin, in which insulin is given and blood glucose is measured at regular intervals. Thirty minutes after the insulin is administered, blood glucose level is usually lower but not less than half of the fasting glucose level. Glucose levels usually return to normal after about 90 minutes. In people who have hypoglycemia, the glucose levels may drop lower and be slower to return to normal.

insulin tolerance test

,

ITT

A test to determine a patient's hormonal responses to induced hypoglycemia. After 0.1 IU of insulin/kg is given intravenously, blood is drawn at regular intervals to measure serum cortisol in patients with suspected adrenal insufficiency or growth hormone in suspected growth hormone deficiency. The goal of the test is to stress the body with low blood glucose levels (> 40 mg/dl).

CAUTION!

The test should be administered only by experienced professionals in order to reduce the risk of severe hypoglycemic reactions.
References in periodicals archive ?
J-L) The blood glucose levels during the insulin tolerance test (ITT) in 4 hr-fasted mice were assessed at 1DPN, 1WPN, and 1MPN.
At 12 week insulin tolerance test (ITT) was per-formed.
It has been suggested that the short synacthen test may be used instead of the insulin tolerance test to evaluate the hypothalamic-pituitary adrenal axis but it has produced some falsely reassuring results with potentially serious consequences14.
Effects of arsenic on the oral glucose tolerance test (OGTT; A) and the insulin tolerance test (ITT; B) in female mice with or without ovariectomy.
Insulin tolerance test in rabbits: The rabbits were divided into 5 groups with 6-7 animals in each group.
The other method developed to evaluate insulin sensitivity in vivo involved the use of the insulin tolerance test, which is based on the change of plasma glucose level after a bolus injection of regular insulin (Ginsberg 1977), and its results reflected the insulin sensitivity.
After a treatment period of 2 weeks, intraperitoneal glucose tolerance test (1PGTT), intraperitoneal insulin tolerance test (IPITT), fasting insulin-, triglyceride-, cholesterol levels and pro-inflammatory markers (IL-1[beta]and IL-6) were evaluated.
To determine whether dietary kudzu supplementation affected insulin-induced glucose clearance, insulin tolerance tests (ITT) were performed on kudzu-treated ob/ob and lean control mice.
Because hyperinsulinemic-euglycemic clamping is not easy to deal with in terms of animal handling, and is time and labor intensive, GTTs (preferably intraperitoneal or intravenous) combined with insulin tolerance tests (ITTs) are an advisable alternative for exploring pollutant effects on insulin sensitivity.

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