insulin tolerance test

ITT

A test to determine a patient's hormonal responses to induced hypoglycemia. After 0.1 IU of insulin/kg is given intravenously, blood is drawn at regular intervals to measure serum cortisol in patients with suspected adrenal insufficiency or growth hormone in suspected growth hormone deficiency. The goal of the test is to stress the body with low blood glucose levels (> 40 mg/dl).

CAUTION!

The test should be administered only by experienced professionals in order to reduce the risk of severe hypoglycemic reactions.

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References in periodicals archive ?

ipGTT: intraperitoneal glucose tolerance test; ipITT: intraperitoneal insulin tolerance test.

Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats

Intraperitoneal glucose tolerance test (GTT) (a) and insulin tolerance test (ITT) (b) were performed and area under curve (AUC) was measured for the GTT.

Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

At the end of 12 weeks insulin tolerance test (ITT) was performed in all groups.

COMPARATIVE EFFECTS OF LOSARTAN AND PIOGLITAZONE ON INSULIN RESISTANCE IN RATS

Response to insulin tolerance test on admission and first control visit MAY 2009 AUGUST 2009 Time (minute) 0.

Spontaneous remission of acromegaly following subclinical pituitary apoplexy/Subklinik hipofizer apopleksiyi takiben spontan remisyona giren akromegali

Once suspected, the definitive diagnosis can be confirmed by laboratory evaluation of adrenocortical function by short synacthen test, insulin tolerance test and metyrapone test13.

Comparison of low dose short synacthen test (1 microgram) with standard dose short synacthen test (250 microgram) in patients of adrenal insufficiency

Herrmann's study, which was funded by Novo Nordisk, 6 of the 18 head trauma patients with pituitary deficiency had GH deficiency, defined as a GH response of less than 9 [micro]g/L to stimulation with GH releasing hormone plus arginine, and of less than 3 [micro]g/L to the insulin tolerance test (ITT).

Hypopituitarism seen after severe head trauma

This is a very practical issue because inexperienced junior colleagues have aborted an insulin tolerance test (ITT) when the patient was symptomatic and the glucose meter reading was 35 mg/ dL.

Biochemical Investigations in Laboratory Medicine

The hypothalamic-pituitary-adreno-cortical glucocorticoid axis can be studied during the insulin tolerance test. Cortisol secretion is normally elicited by hypoglycemia.

The endocrinology of growth failure

T2D: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor-a IL-6: Interleukin-6 JNK: Jun N-terminal kinase IKK[beta]: I[kappa]B kinase HFD: High-fat diet DPP-4: Dipeptidyl-peptidase 4 GLP-1: Glucagon-like peptide 1 GIP: Glucose-dependent insulinotropic peptide WAT: White adipose tissue DIO: Diet-induced obese RCT: Randomized controlled trial WT: Wild-type TC: Total cholesterol TG: Triglycerides GTT: Glucose tolerance test ITT: Insulin tolerance test AUC: Area under the curve H&E: Hematoxylin and eosin AP1: Activator protein 1 AMPK: AMP-activated protein kinase mTOR: Mammalian target of rapamycin NAFLD: Nonalcoholic fatty liver disease HOMA-IR: Homeostasis model assessment index-insulin resistance SEM: Standard error of the mean.

Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

In order to measure insulin sensitivity, we performed an insulin tolerance test. Glimepiride-treated mice are as sensitive to insulin as control-treated mice (c).

Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

C, Insulin tolerance test results for control (n=4 mice), HFD (n=4 mice) and HFD + rimonabant (n=4 mice) groups.

Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated [Ca.sup.2+] channels in skeletal muscle in HFD-fed mice

The insulin tolerance test revealed the suppression of C-peptide as well as the poor responses of ACTH and cortisol (Table 2(c)).

Asymptomatic Congenital Hyperinsulinism due to a Glucokinase-Activating Mutation, Treated as Adrenal Insufficiency for Twelve Years